Dear Markus,
I guess it depends on how you plan to make the estimation:
1) If it is by NCA, other programs will do this
2) If it is as model-based, non-linear regression, many programs will
do it (incl NONMEM)
3) If you want to analyse the individual data using a previous
population PK model as prior, NONMEM and other non-linear mixed effects
models are probably preferable.
Best regards,
Mats
Mats Karlsson, PhD
Professor of Pharmacometrics
FIRST WORLD CONFERENCE ON PHARMACOMETRICS, 5-7 September 2012, Seoul (
<
http://www.go-wcop.org/> www.go-wcop.org)
Dept of Pharmaceutical Biosciences
Faculty of Pharmacy
Uppsala University
Box 591
75124 Uppsala
Phone: +46 18 4714105
Fax + 46 18 4714003
From: owner-nmusers
Behalf Of markus joerger
Sent: 02 September 2012 04:40
To: NONMEM
Subject: [NMusers] single-patient AUC
dear NM-community,
Is NONMEM reliably used for single-patient AUC-calculation in cases of
linear PK, or is e.g. WinNonLin (or similar software) preferred in such
cases?
best regards,
Markus
--
Markus Joerger MD PhD
Associate Professor
Medical Oncology&Clinical Pharmacology
Cantonal Hospital
9007 St. Gallen
Switzerland
markus.joerger
markus.joerger
Phone: +41-765591070
Fax: +41-714946325
Received on Sun Sep 02 2012 - 02:17:59 EDT
