NONMEM Users Network Archive

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RE: single-patient AUC

From: Mats Karlsson <mats.karlsson>
Date: Sun, 2 Sep 2012 08:17:59 +0200

Dear Markus,

 

I guess it depends on how you plan to make the estimation:

1) If it is by NCA, other programs will do this

2) If it is as model-based, non-linear regression, many programs will
do it (incl NONMEM)

3) If you want to analyse the individual data using a previous
population PK model as prior, NONMEM and other non-linear mixed effects
models are probably preferable.

Best regards,

Mats

 

Mats Karlsson, PhD

Professor of Pharmacometrics

 

FIRST WORLD CONFERENCE ON PHARMACOMETRICS, 5-7 September 2012, Seoul (
<http://www.go-wcop.org/> www.go-wcop.org)

 

Dept of Pharmaceutical Biosciences

Faculty of Pharmacy

Uppsala University

Box 591

75124 Uppsala

 

Phone: +46 18 4714105

Fax + 46 18 4714003

 

From: owner-nmusers
Behalf Of markus joerger
Sent: 02 September 2012 04:40
To: NONMEM
Subject: [NMusers] single-patient AUC

 

dear NM-community,

Is NONMEM reliably used for single-patient AUC-calculation in cases of
linear PK, or is e.g. WinNonLin (or similar software) preferred in such
cases?

best regards,
Markus



--

Markus Joerger MD PhD
Associate Professor
Medical Oncology&Clinical Pharmacology
Cantonal Hospital

9007 St. Gallen
Switzerland
markus.joerger
markus.joerger
Phone: +41-765591070
Fax: +41-714946325

 


Received on Sun Sep 02 2012 - 02:17:59 EDT

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