NONMEM Users Network Archive

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RE: Dummy dose

From: Bill Bachman <bachmanw>
Date: Thu, 24 May 2012 15:08:44 -0400

If you put in a zero, it's not a dose...
 
One is usually used as a "unit dose", a bioavailabity term can be modeled
to account for scaling the dose to accomodate to observed dependent variable
values.

  _____

From: owner-nmusers
Behalf Of siwei Dai
Sent: Thursday, May 24, 2012 2:39 PM
To: nmusers
Subject: [NMusers] Dummy dose


Dear NMusers:
 
Can anyone give me some suggestions on how to use dummy dose and dummy
observation? I cannot find a clear explanation on how to use it. I see in a
thread discussion that a single unit (normally '1') should be put in, but
why not using "0" or a small number (such as 0.001)? Don't you need to worry
that '1' will create some artifact if the real dose is close to '1'?
 
Thank you very much in advance for your time.
 
Regards,
 
Siwei

Received on Thu May 24 2012 - 15:08:44 EDT

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