NONMEM Users Network Archive

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Re: Question about interoccation variability

From: Xu, Claire <smartxucong>
Date: Thu, 12 Jul 2012 09:11:13 -0400

Hi Nick,
Thanks for your helpful comment. I will test BOV + BSV on my absorption
model parameters first.
Sorry for my typo. I meant neither of the models improved the fit.
Thanks again for your help.
Best,
Claire

On Thu, Jul 12, 2012 at 8:07 AM, Nick Holford <n.holford

> Claire,
>
> See below:
>
>
> On 11/07/2012 9:45 p.m., Xu, Claire wrote:
>
>> Hi Nick,
>> Thank you a lot for clarifying how to incorporate BOV in the model.
>> I tested BOV on F1 with the same option as well as variable BOVs on F1
>> from different occasions. But either of them improved the fitting.
>>
>
> I am not sure what you mean here. Do you mean that NEITHER of them
> improved the fit? If that is the case then it would be compatible with your
> other observation that AUC is very similar across occasions which suggests
> that there is negligible BOV in CL or F. I find that a bit surprising but
> it is not impossible.
>
>
>
> Actually according to the results from non-compartmental analysis,
>> AUC0-inf are very similar across different occasions, while a trend of
>> difference in Cmax and Tmax was observed. Do you think that more complex
>> absorption models would help?
>>
>
> Because you are do see BOV in Cmax and Tmax then it seems you should try
> to focus on looking for BSV+BOV on your absorption model parameters (Ka,
> Tlag). Of course you can also work on the absorption model structure as
> well.
>
>
>
> Open to any comments.
>> Thanks again for your great input.
>> Best,
>> Claire
>>
>>
>>
> --
> Nick Holford, Professor Clinical Pharmacology
>
> First World Conference on Pharmacometrics, 5-7 September 2012
> Seoul, Korea http://www.go-wcop.org
>
> Dept Pharmacology & Clinical Pharmacology, Bldg 505 Room 202D
> University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand
> tel:+64(9)923-6730 fax:+64(9)373-7090 mobile:+64(21)46 23 53
> email: n.holford
> http://www.fmhs.auckland.ac.**nz/sms/pharmacology/holford<http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford>
>
>
>
>
>


--
Xu, Claire
Ph.D Candidate
Division of Clinical Pharmacology, Wishard Hospital
Indiana University School of Medicine
1001 West 10th Street, Myers W7122
Indianapolis, IN 46202
T - 317/7558242

Received on Thu Jul 12 2012 - 09:11:13 EDT

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