NONMEM Users Network Archive

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Modeling capacity limited PD response

From: Bilal Abuasal <bilalasal>
Date: Thu, 23 Aug 2012 07:58:34 -0700 (PDT)

Hi: I'm trying to develop a pop PK/PD model for a drug X that induces the=
 secretion of the hormone Y, we are using IV infusion of X to reach t=
he steady state,  hormone Y secretion is stimulated initially by X infusi=
on, however after 30 minutes no more Y hormone is secreted and Y levels sta=
rt to decrease, which might be attributed to saturating  the excretion =
 of Y by the gland (No more hormone left in the gland). Can any one share=
 with me a code or a modeling idea to model a scenario like that? or at l=
east refer some article to read. Abuasal
Received on Thu Aug 23 2012 - 10:58:34 EDT

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