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Re: Plasma and Urine data

From: Alison Boeckmann <alisonboeckmann>
Date: Thu, 09 Aug 2012 05:49:25 -0700

See also
NONMEM Users Guide - Part V Introductory Guide
Chapter 7 - $SUBROUTINE Record and $PK Record
4.3.3. Scaling by a Data Item


On Wed, Aug 8, 2012, at 02:31 PM, Denney, William S. wrote:

Hi Norman,


I believe that you can use the standard ADVAN routines by putting the
urine as the excretion compartment (e.g. CMT = 3 for ADVAN3). What you
would do is:


· Put an EVID=2 with CMT=3 at TIME 0 for each subject (to =
turn
on the output compartment),

· Put a row with EVID=0, CMT=3, and your observed AMOUNT (=
not
concentration) of drug in the urine at the end of its observation
interval,

· After the EVID=0, CMT=3 row in the above bullet, you nee=
d to
reset the compartment to 0 concentration by turning it off then on:
EVID=2, CMT=-3 (note the negative to turn off)
EVID=2, CMT=3 (positive to turn on)

· Then use F3=THETA(X) to estimate the % renal excretion
(relative to F1 bioavailability); set V3=1.


The minimal, more concrete example of the data file is for subject 1
dosed at time 0 with 5.5 mg measured in the urine at time 4 and 10 mg
measured in the urine at time 12:


ID TIME CMT EVID AMT

# Reset the subject

1 0 . 3 .

# Turn on the urine compartment

1 0 3 2 .

# Dose with 10 mg

1 0 1 1 10

# Any normal intermediate plasma concentration rows should go here.

1 1 2 0 2.2

# Amount in the urine at 4 hours

1 4 3 0 5.5

# Reset and restart the urine compartment

1 4 -3 2 .

1 4 3 2 .


Thanks,


Bill


From: owner-nmusers
[mailto:owner-nmusers
Sent: Wednesday, August 08, 2012 4:40 PM
To: nmusers
Subject: [NMusers] Plasma and Urine data


Dear NMusers,


I am working on a dataset with drug concentration data in both plasma
and urine. I found most of the control streams dealing with urine data
previously posted here were based on user-defined differential
equations. My question is whether a normal ADVAN1 control stream and
dataset can be changed to allow urine data to be used. If so, what has
to be change in the control stream and the dataset? I’d sincerely
appreciate it, if somebody can share with me a sample control stream to
simultaneously fit the plasma and urine data.


Kind regards,


Norman Zhou
--
  Alison Boeckmann
  alisonboeckmann


Received on Thu Aug 09 2012 - 08:49:25 EDT

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