NONMEM Users Network Archive

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RE: How to Increase Maximum NO. of Evaluations of Differential Equation in NONMEM 7

From: Fidler,Matt,FORT WORTH,R&D <Matt.Fidler>
Date: Thu, 23 Jun 2011 09:53:12 -0500

Li Li,

In addition you may try ADVAN9, though ADVAN13 may have advantages over ADV=
AN9.

Matt.

-----Original Message-----
From: owner-nmusers
 Behalf Of Luann Phillips
Sent: Wednesday, June 22, 2011 4:44 PM
To: Li Li
Cc: nmusers
Subject: Re: [NMusers] How to Increase Maximum NO. of Evaluations of Differ=
ential Equation in NONMEM 7

Li Li,

If this is the model that you have described previously, you may want to
  try ADVAN8 or ADVAN13. With the cusps that the on/off nature of your
rate constant a stiff diff. eq. solver may perform better.

best regards,

Luann Phillips
Director PK/PD
Cognigen Corporation

Li Li wrote:
> Hi,
>
> I am using ADVAN 6 to do some PKPD modeling and got this error message:
> NUMERICAL DIFFICULTIES WITH INTEGRATION
> ROUTINE.
>
> MAXIMUM NO. OF EVALUATIONS OF DIFFERENTIAL EQUATIONS, 1000000,
> EXCEEDED.
>
> I know in NONMEM 6 you may use following code to increase maximum number
> of integration of differential equation:
> "FIRST
> " COMMON /PRCOMG/ IDUM1,IDUM2,IMAX,IDUM4,IDUM5
> " INTEGER IDUM1,IDUM2,IMAX,IDUM4,IDUM5
> " IMAX=100000000
> But in NONMEM 7 it gave error message:
> (WARNING 113) VERBATIM CODE CONTAINS "COMMON". IF THIS IS NOT A
> USER-DEFINED COMMON, IT SHOULD BE REPLACED BY THE APPROPRIATE MODULE.
> CREATING MUMODEL ROUTINE...
>
> Thus, how can I increase maximum number of integration of differential
> equation in NONMEM 7?
>
> Thank you.
>
> lili

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Thank you.
Received on Thu Jun 23 2011 - 10:53:12 EDT

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