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Re: Modeling concentration data with imprecise sampling time

From: Leonid Gibiansky <LGibiansky>
Date: Thu, 02 Jun 2011 12:45:00 -0400

Michael,
I do not think you can change observation time, but you can change
infusion duration using
RATE=-2 (in the data file)
D1=THETA(*)*EXP(ETA()) (in the control stream)

Alternative is to exclude data points that are inconsistent with the
profiles.

Leonid

--------------------------------------
Leonid Gibiansky, Ph.D.
President, QuantPharm LLC
web: www.quantpharm.com
e-mail: LGibiansky at quantpharm.com
tel: (301) 767 5566



On 6/2/2011 11:44 AM, mdkzone
>
> All:
> I have a data set following a constant rate 1-hour infusion where the
> time of 1-hour sample is imprecise. In some cases the "1-hr" sample was
> taken prior to infusion termination as it was intended; however, in
> others it was quite apparently take after the infusion ended. I'm
> thinking of modeling with the time of the "1-hr" sample as a "theta".
> Does anyone have a NONMEM coding example showing how to do this? Any
> other suggestions as to how to handle this would be appreciated as well.
>
> Thanks,
> Michael
Received on Thu Jun 02 2011 - 12:45:00 EDT

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