NONMEM Users Network Archive

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Modeling concentration data with imprecise sampling time

From: mdkzone
Date: Thu, 02 Jun 2011 11:44:45 -0400

   I have a dataset following a constant rate 1-hour infusion where the ti=
me of 1-hour sampleis imprecise. In some cases the "1-hr" sample was take=
n prior to infusion termination as it was intended; however, in others it=
 was quite apparently take after the infusion ended. I'm thinking of mode=
ling with the time of the "1-hr" sample as a "theta". Does anyone have a=
 NONMEM coding example showing how to do this? Any other suggestions as=
 to how to handle this would be appreciated as well.


Received on Thu Jun 02 2011 - 11:44:45 EDT

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