NONMEM Users Network Archive

Hosted by Cognigen

Modeling concentration data with imprecise sampling time

From: mdkzone
Date: Thu, 02 Jun 2011 11:44:45 -0400



All:
 
   I have a dataset following a constant rate 1-hour infusion where the ti=
me of 1-hour sampleis imprecise. In some cases the "1-hr" sample was take=
n prior to infusion termination as it was intended; however, in others it=
 was quite apparently take after the infusion ended. I'm thinking of mode=
ling with the time of the "1-hr" sample as a "theta". Does anyone have a=
 NONMEM coding example showing how to do this? Any other suggestions as=
 to how to handle this would be appreciated as well.


Thanks,
Michael


Received on Thu Jun 02 2011 - 11:44:45 EDT

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to: nmusers-request@iconplc.com.

Once subscribed, you may contribute to the discussion by emailing: nmusers@globomaxnm.com.