NONMEM Users Network Archive

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how to include inconsistent infusion rate into the model

From: Tomi Hendrayana <s6tohend>
Date: Fri, 12 Aug 2011 15:45:57 +0200

Dear all,

I ask to the experts here concerning my problem. I am
beginner in using NONMEM and want to include an
inconsistent infusion rate into the model. I collected
sample from cancer patient. Baxter infusion pumps were
used for 24 – 48 hour continuous venous infusion. I
observed that the plasma concentrations varied especially
at the end of infusion, probably due to inconsistent
infusion rate.
Could someone share his experiences with me? Any
suggested code for it will be great help. All responses
will be highly appreciated, thanks in advance and have a
nice weekend ;-)

-Tomi Hendrayana
Klinische Pharmazie
Pharmazeutisches Institut
Universitaet Bonn
an der Immenburg 4
D-53121 Bonn

Received on Fri Aug 12 2011 - 09:45:57 EDT

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