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Re: allometric scaling for renal elimination drug

From: Nick Holford <n.holford>
Date: Thu, 04 Aug 2011 07:47:26 +1200


The answer to your simple question is "yes".
This paper describes the use of allometric scaling for GFR -- the
prototype for all renal elimination processes.

Rhodin MM, Anderson BJ, Peters AM, Coulthard MG, Wilkins B, Cole M, et
al. Human renal function maturation: a quantitative description using
weight and postmenstrual age. Pediatr Nephrol. 2009;24(1):67-76.

Best wishes,


On 4/08/2011 2:46 a.m., CHAO ZHANG wrote:
> Dear NMuser,
> I have a question about allometric scaling. Can allometric scaling be
> used to a renal elimination drug?
> Thanks.
> Chao Zhang
> Division of Clinical Pharmacology
> Department of Medicine
> University of Cape Town
> K45, Old Main Building
> Groote Schuur Hospital
> Observatory 7925
> Cape Town South Africa
> Tel : +27 021 4047719
> Fax: +27 021 4481989

Nick Holford, Professor Clinical Pharmacology
Dept Pharmacology& Clinical Pharmacology
University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand
tel:+64(9)923-6730 fax:+64(9)373-7090 mobile:+64(21)46 23 53
email: n.holford
Received on Wed Aug 03 2011 - 15:47:26 EDT

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