NONMEM Users Network Archive

Hosted by Cognigen

WFN for NONMEM 7 - version 702

From: Nick Holford <n.holford>
Date: Sun, 14 Feb 2010 10:14:33 +1300

Hi,

I have uploaded a new version of Wings for NONMEM (version 702) to
http://wfn.sourceforge.net

Version Notes

14 February 2010 Version 702/616

Users of Monolix can create a model building table from Monolix projects
with the mlxmbt command. The format of the output is the same as that
used with the nmmbt command. Note: When Monolix is asked to compute the
log likelihood it adds a constant term equal to Obs*ln(2*pi) that is not
added by NONMEM. The Monolix derived “Obj” value reported by the mlxmbt
command can be converted to the equivalent value computed by NONMEM by
subtracting Obs*ln(2*pi) from the Monolix value. Unfortunately Monolix
does not save the number of observations (Obs) so this cannot currently
be done automatically by mlxmbt.

WFN Version 702 and 616 have an improved model building summary table
format. The nmmbt.txt file sequence of column headings is more likely to
be presented in a useful format when multiple runs are combined.

The WFN extended control stream format supports the use of $OMEGA
parameter names when MU referencing is used. When the MU index is the
same as the corresponding ETA used for that MU then MU referencing can
be coded without counting ETA values e.g.

$THETA 10 ; POP_CL
$OMEGA 0.5 ; PPV_CL [this corresponds to eta(1)]

$PK
MU_1=LOG(POP_CL)
CL=EXP(MU_1+ETA(1))

Can be written:

$PK
MU_PPV_CL=LOG(POP_CL)
CL=EXP(MU_PPV_CL+PPV_CL)

Note: the use of parameter names for MU referencing is optional. If you
use the $OMEGA parameter name then WFN will replace it with a suitable
numeric value for NM-TRAN to process otherwise the code will not be
changed by WFN.

A bug has been fixed for reporting the estimation method. Version 701
reported FOCE when it should have been FOCEI.


Please let me know if/when you discover bugs.

Nick

--
Nick Holford, Professor Clinical Pharmacology
Dept Pharmacology & Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
n.holford
mobile: +64 21 46 23 53
http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford

Received on Sat Feb 13 2010 - 16:14:33 EST

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to: nmusers-request@iconplc.com.

Once subscribed, you may contribute to the discussion by emailing: nmusers@globomaxnm.com.