NONMEM Users Network Archive

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RE: simulation question

From: Gibiansky, Ekaterina <Ekaterina.Gibiansky>
Date: Fri, 6 Feb 2009 08:33:44 -0500

Yes, it is fixed in Nonmem VII.

Ekaterina Gibiansky
Senior Director, PKPD, Modeling & Simulation
ICON Development Solutions

-----Original Message-----
From: owner-nmusers
On Behalf Of Nick Holford
Sent: Friday, February 06, 2009 6:39 AM
To: nmusers
Subject: Re: [NMusers] simulation question


I dont understand why this wasn't fixed in NONMEM VI. It was a well
known bug in NONMEM V and has caused lots of grief for users.

I hope the NONMEM VII developers have got this high on their list of
NONMEM bugs that need to be fixed.


>> Dear users,
>> I am trying to compare several specific PK/PD study designs by:
>> -- run 200 simulations with the final model (develope from original
>> dataset)
>> -- fit the final model to the 200 simulated dataset
>> To achieve above, I used $SIM SUBPROB=200 option
>> however, nonmem would completely stop after running
>> into estimation problem at one specific simulation/estimation cycles,

>> for some designs it stop even before 10th iterations.
>> Is there anyway nonmem could continue go on?
>> Or, does someone know alternative way to achieve the goal?
>> thanks

Nick Holford, Dept Pharmacology & Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New

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Received on Fri Feb 06 2009 - 08:33:44 EST

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