NONMEM Users Network Archive

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Re: simulation question

From: Nick Holford <n.holford>
Date: Sat, 07 Feb 2009 00:39:14 +1300


I dont understand why this wasn't fixed in NONMEM VI. It was a well
known bug in NONMEM V and has caused lots of grief for users.

I hope the NONMEM VII developers have got this high on their list of
NONMEM bugs that need to be fixed.


>> Dear users,
>> I am trying to compare several specific PK/PD study designs by:
>> -- run 200 simulations with the final model (develope from original
>> dataset)
>> -- fit the final model to the 200 simulated dataset
>> To achieve above, I used $SIM SUBPROB=200 option
>> however, nonmem would completely stop after running
>> into estimation problem at one specific simulation/estimation cycles,
>> for some designs it stop even before 10th iterations.
>> Is there anyway nonmem could continue go on?
>> Or, does someone know alternative way to achieve the goal?
>> thanks

Nick Holford, Dept Pharmacology & Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand

Received on Fri Feb 06 2009 - 06:39:14 EST

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