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Bootstrap analysis

From: Varsha Mehta <varsham>
Date: Tue, 21 Apr 2009 15:50:03 -0400


I have bootstrap analysis (my first) parameter estimates and model
parameters. The PDxPOP/NONMEM manual I have does not provide
any guidance as to how I can statistically compare these two (or do I
need to?). I also have histograms for the thetas in bootstrap analysis.
I can make some visual judgements but is there a way to statistically
compare the two results (bootstrap v model) built in to the NONMEM
that I can use to quickly get some statistical comparison results?

How else can I use the bootstrap results to confirm the fact that the
model I have is the best fit for the data?

Thanks in advance.

Varsha Mehta, MS(CRDSA), Pharm.D., FCCP
Clinical Associate Professor
Pharmacy, Pediatrics and Communicable Diseases
Clinical Pharmacist Neonatal Critical Care
University of Michigan
(O) 734-936-8985
(F) 734-936-6946

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Received on Tue Apr 21 2009 - 15:50:03 EDT

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