Just to answer quickly on the question directed to me: Yes, you =
understood it correctly.
To implement this in practice, since your NONMEM dataset only includes =
one level for the covariate (all subjects have the same covariate =
value), you will need to make a small addition to the SCM configuration =
Lets assume DIS=1 is the covariate, where 1 codes for a new indication =
(which was not present in the legacy data used to generate the prior), =
or a new subpopulation, e.g. children/adolescents, where only adults =
where present in the legacy data.
You would then need to add this to the scm configuration file:
Other than that, it is also a little tricky to generate the NONMEM =
control stream with NWPRI on all parameters (of the base model).
PsN has an automatic function for generating this code (option to =
update_inits), but it may be good to check manually.
Jakob Ribbing, Ph.D.
Senior Consultant, Pharmetheus AB
Cell/Mobile: +46 (0)70 514 33 77
Phone, Office: +46 (0)18 513 328
Uppsala Science Park, Dag Hammarskjölds väg 36B
SE-752 37 Uppsala, Sweden
Received on Fri May 17 2019 - 09:08:37 EDT