[NMusers] Re: Random number generation

From: Sebastien Bihorel <sebastien.bihorel_at_cognigencorp.com>
Date: Mon, 3 Jun 2019 16:54:46 -0400 (EDT)


Thanks Tingjie for your suggestion

Unfortunately, as is, the suggested code is rejected by NONMEM 7.3 if used in $ERROR. Some additional setup calls might be required.

An (admittedly heavy-handed) alternative that actually works is to create and import a fortran routine (see NONMEM help topic about FUNCA, or VECTRA).

runif.f90:
FUNCTION FUNCA(X,X1,X2)
USE SIZES, ONLY: DPSIZE
REAL(KIND=DPSIZE) :: X,X1,X2,FUNCA
FUNCB = RAND()
RETURN
END

Control stream:
...
$SUBROUTINES ADVAN_ TRANS_ OTHER=runif.f90
...
$ERROR
VECTRA(1) = 0
VECTRA(2) = 0
VECTRA(3) = 0

RND = FUNCA(VECTRA)
...


From: "Tingjie Guo" <iam_at_tingjieguo.com>
To: "Sebastien Bihorel" <sebastien.bihorel_at_cognigencorp.com>, nmusers_at_globomaxnm.com
Sent: Monday, June 3, 2019 12:58:56 PM
Subject: Re: Random number generation

Hi Sebastien,

As far as I know, you could write verbatim code to generate random numbers during estimation. E.g:

$PK|$DES|$ERROR
RAN = any value ; initialization
"RAN = RAND(0) ; start verbatim code

A random number between 0 and 1 from uniform distribution will be assigned to RAN. This function is called for each record of your input data. I believe it's also possible to call it more/fewer times through checking ICALL.

Warm regards,
Tingjie





From: owner-nmusers_at_globomaxnm.com <owner-nmusers_at_globomaxnm.com> on behalf of Sebastien Bihorel <sebastien.bihorel_at_cognigencorp.com>
Sent: Thursday, May 30, 2019 12:34
To: nmusers_at_globomaxnm.com
Subject: [NMusers] Random number generation

Hi,

Is it possible for NONMEM to generate a random number during an estimation run?

Thank you

Sebastien Bihorel




Received on Mon Jun 03 2019 - 16:54:46 EDT

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