As mentioned back in August, the failure occurs because your TIMEOUT parameter in the pnm file was not long enough, and a time out occurred, and NONMEM is not properly recovering from this. Therefore, the SEE’s should not be believed, as the subjects from the timed out processes would not be included.
Robert J. Bauer, Ph.D.
ICON Early Phase
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Gaithersburg, MD 20878
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Mobile: (925) 286-0769
From: Robert Bauer [mailto:bobjbauer_at_att.net]
Sent: Friday, February 08, 2019 8:08 PM
To: Bauer, Robert
Subject: Fw: [NMusers] Different OBJ after covariance with parallel and IMPMAP
----- Forwarded Message -----
From: Mark Sale <msale_at_nuventra.com>
Cc: nmusers_at_globomaxnm.com <nmusers_at_globomaxnm.com>
Sent: Monday, February 4, 2019 10:50:28 AM PST
Subject: [NMusers] Different OBJ after covariance with parallel and IMPMAP
I've notices several times that when
the "one more iteration for variance" will fail on one (or more) of the processes. When it does this, the OBJ will be lower than the last iteration of the
parameter estimation. It seems that when this happens, NONMEM uses the default value (0) for OBJI for the data sent to that process, resulting in a lower OBJ. So, you can, in principle, rerun the model using the MSF and single process.
But, interestingly, while the OBJ reported in the outfile files seems to be wrong, NONMEM will still report SEE etc. Can the SEE values in this case be believed?
Mark Sale M.D.
Senior Vice President, Pharmacometrics
Nuventra Pharma Sciences, Inc.
2525 Meridian Parkway, Suite 200
Durham, NC 27713
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Received on Fri Feb 08 2019 - 23:20:39 EST