Re: [NMusers] Simulation error

From: Ayyappa Chaturvedula <ayyappach_at_gmail.com>
Date: Mon, 22 Apr 2019 10:41:22 -0500

Thank you all. The issue is solved. I appreciate your help.

Regards,
Ayyappa

> On Apr 22, 2019, at 8:56 AM, Leonid Gibiansky <lgibiansky_at_quantpharm.com> w=
rote:
>
> Nonmem needs to allocate memory for all variables stored in the MSF file. =
For that, it counts THETAs and ETAs and SIGMAs in the control stream. If som=
e of them are not listed (often we do not need all parameters of the model f=
or a specific simulation), one needs to tell the program how much memory is n=
eeded
> (e.g., $SIZES LTH= 7 LVR= 2)
>
> One can always keep all THETAs and OMEGAs in the controls stream, for exam=
ple by adding dummy variable (in the ERROR block)
> TEMP=THETA(5)+ETA(3)+EPS(2)....
> listing all unused parameters (or all parameters)
>
> The second problem is related to the absence of one of the MSF files. MSF o=
ptions actually reads two files, FILENAME.MSF and FILENAME_ETAS.MSF. Both sh=
ould be in the same file path specified in the control stream for FILENAME.M=
SF file.
>
> Leonid
>
>
>
>
>> On 4/20/2019 11:11 AM, Ayyappa Chaturvedula wrote:
>> Dear All,
>> I am trying to run a simulation using $MSFI option instead of giving $THE=
TA and $OMEGA. One of the model gave the following error and a recommendati=
on:
>> F_LVR AND/OR F_LTH ARE TOO SMALL TO DEAL WITH INPUT FROM MSFI FILE.
>> RECOMMEND INSERTING AS FIRST LINE OF CONTROL STREAM:
>> $SIZES LTH= 7 LVR= 2.
>> I changed the control file with the recommended $SIZES LTH= 7 LVR= 2 a=
s first line in the control file. But, then I get the following error messa=
ge:
>> WARNING: EXTRA MSF FILE COULD NOT BE OPENED: msf2_ETAS
>> *** Error in `./nonmem': malloc(): memory corruption: 0x000000000400f470 *=
**
>> I appreciate any help resolving this issue.
>> Regards,
>> Ayyappa

Received on Mon Apr 22 2019 - 11:41:22 EDT

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