[NMusers] Workshop on Convolution-based modeling approach

From: roberto gomeni <roberto.gomeni_at_pharmacometrica.com>
Date: Mon, 22 Oct 2018 13:41:28 +0200

Workshop on Convolution-based modeling approach

March 11-13, 2019: Fort Lauderdale, FL (USA)

 

This three-day, hands-on course provides a working knowledge of the theories
and application of the state-of-the-art convolution-based modeling approach
to characterize complex PK profiles, to establish in-vitro in-vivo
correlation (IVIVC) and to optimize ER and LAI formulation development using
the exposure-response relationship.

 

The course is structured in the following sections:

1. Convolution based model

* Development of convolution-based models

* Modeling single and repeated doses administration using
convolution-based approach in NONMEM

* Development of an R based simulator for convolution-based models

 

2. Modeling complex absorption process

* Definition and implementation in NONMEM of typical and user
defined input function models, to characterize delayed, multiple peaks and
time dependent absorption process

* Characterize the complex in-vivo absorption processes of extended
release formulations (ER) and Long Acting Injectable (LAI) formulations
using convolution-based approach

 

3. Implementing Level A IVIVC

* Definition of Level A IVIVC

* Implementation of a Level A IVIVC using convolution-based models
in NONMEM

* The concept of time-scaling

* Definition of time scaling functions for assessing IVIVC in NONMEM

* Evaluate the quality of an IVIVC model and the predictive
performances of an IVIVC model

 

4. Optimizing drug performances

* Definition of drug/formulation optimization strategies using
surface-response analysis, clinical trial simulation and convolution-based
models

* Development of an R based optimizer

* Determine the relationship between drug delivery and clinical
benefit using the outcome of an IVIVC analysis

* Determine dose, dosage regimen and dosing strategies for
optimizing the clinical benefit using the outcomes of the IVIC analysis

 

Interactive and real life examples, taken from actual industry experience
using R and NONMEM will be presented and discussed in the hands-on sections
to illustrate how to deal with delayed, multiple peaks and time dependent
absorption process, how to establishing a Level A IVIVC using a
model-informed approach and how to develop optimized formulations with an
in-vivo drug release suitable to maximize the clinical benefit of a
treatment.

 

For additional information, visit our website:
<https://www.pharmacometrica.com/next-workshop>
https://www.pharmacometrica.com/next-workshop

 

 

Roberto Gomeni, PhD.

Pharmacometrica

Longcol, 12270 La Fouillade (France)

E-mail: <mailto:roberto.gomeni_at_pharmacometrica.com>
roberto.gomeni_at_pharmacometrica.com

www.pharmacometrica.com <http://www.pharmacometrica.com/>

Next workshops on pharmacometrics:
<https://www.pharmacometrica.com/next-workshop>
https://www.pharmacometrica.com/next-workshop

 

 




Received on Mon Oct 22 2018 - 07:41:28 EDT

This archive was generated by hypermail 2.3.0 : Fri Sep 27 2019 - 17:01:21 EDT