[NMusers] RE: Using Root-finding techniques to find Cmax/Tmax

From: Bauer, Robert <Robert.Bauer_at_iconplc.com>
Date: Mon, 14 May 2018 17:15:47 +0000

Nick:
A cmax_root_finder.zip file is now supplied.
nonmem_reserved_general is not intended to be humanly read, but used in the control stream for easy access of reserved variables. A copy is also in ..\util of your NONMEM installation. Use of it is described in ..\guides\intro7.pdf


Robert J. Bauer, Ph.D.
Senior Director
Pharmacometrics R&D
ICON Early Phase
820 W. Diamond Avenue
Suite 100
Gaithersburg, MD 20878
Office: (215) 616-6428
Mobile: (925) 286-0769
Robert.Bauer_at_iconplc.com<mailto:Robert.Bauer_at_iconplc.com>
www.iconplc.com<http://www.iconplc.com/>

From: Nick Holford [mailto:n.holford_at_auckland.ac.nz]
Sent: Monday, May 14, 2018 9:54 AM
To: Bauer, Robert; nmusers_at_globomaxnm.com
Subject: RE: Using Root-finding techniques to find Cmax/Tmax

Hi Bob,

Thanks for preparing the examples. I found the “nonmem reserved general” file something of a challenge – I could barely understand a line of it.
Any chance you could zip up all the files into one archive file? I find myself faced with downloading a couple of pages of files one file at a time.

Best wishes,
Nick
--
Nick Holford, Professor Clinical Pharmacology
Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A
University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand
office:+64(9)923-6730 mobile:NZ+64(21)46 23 53 FR+33(6)62 32 46 72
email: n.holford_at_auckland.ac.nz<mailto:n.holford_at_auckland.ac.nz>
http://holford.fmhs.auckland.ac.nz/<http://holford.fmhs.auckland.ac.nz/>
http://orcid.org/0000-0002-4031-2514<http://orcid.org/0000-0002-4031-2514>
Read the question, answer the question, attempt all questions

From: owner-nmusers_at_globomaxnm.com<mailto:owner-nmusers_at_globomaxnm.com> <owner-nmusers_at_globomaxnm.com<mailto:owner-nmusers_at_globomaxnm.com>> On Behalf Of Bauer, Robert
Sent: Monday, May 14, 2018 5:55 PM
To: nmusers_at_globomaxnm.com<mailto:nmusers_at_globomaxnm.com>
Subject: [NMusers] Using Root-finding techniques to find Cmax/Tmax

Dear nmusers:
Because of the recent discussions (topic “Cmax/Tmax in the DES block”) on the proper way of obtaining tmax and cmax with ODE solvers, I have been motivated to provide some examples utilizing root-finding techniques available in ADVAN14 (CVODES) and ADVAN15 (IDAS). Please read the cmax_root_finder.pdf, and view the accompanying example files, located in

https://nonmem.iconplc.com/nonmem/cmax_root_finder<https://nonmem.iconplc.com/nonmem/cmax_root_finder>


Robert J. Bauer, Ph.D.
Senior Director
Pharmacometrics R&D
ICON Early Phase
820 W. Diamond Avenue
Suite 100
Gaithersburg, MD 20878
Office: (215) 616-6428
Mobile: (925) 286-0769
Robert.Bauer_at_iconplc.com<mailto:Robert.Bauer_at_iconplc.com>
www.iconplc.com<http://www.iconplc.com/>



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Received on Mon May 14 2018 - 13:15:47 EDT

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