[NMusers] Open Pharmacometrician Position - Merck KGaA, Darmstadt, Germany

From: Akash Khandelwal <akash.khandelwal_at_merckgroup.com>
Date: Wed, 29 Aug 2018 15:29:55 +0000

Merck is seeking one creative, motivated Pharmacometrician to join its Phar=
macometric team at Darmstadt headquarter (Germany). To apply please visit t=
he careers pages on https://career012.successfactors.eu/career?company=me=
rckgroup and enter the Requisition ID: 181023 or click the link below

A career is an ongoing journey of discovery: our 52,000 people are shaping =
how the world lives, works and plays through next generation advancements i=
n healthcare, life science and performance materials. For 350 years and acr=
oss the world we have passionately pursued our curiosity to find novel and =
vibrant ways of enhancing the lives of others.
Your role:
One of your main tasks is the global support of the Quantitative Pharmacolo=
gy department within Global Early Development. You provide M&S input into C=
linical Development Plans and participate to sound translational science, f=
rom animal to healthy subjects, to patients, to special populations. Furthe=
rmore you plan, perform, interpret, present, track and record M&S-related a=
ctivities within allocated projects and studies. Your tasks include develop=
ing of internal expertise in advanced population PKPD modeling, with emphas=
is on physiological and mechanistic approaches. You Keep up-to-date with sc=
ientific development in M&S, and regulatory guidance and trends. You explor=
e, evaluate and implement appropriate pharmacometric tools and methodologie=
s; participate to the improvement of the M&S processes and technological pl=
atform. In your function as Pharmacometrician (m/f) you will represent the =
whole of Quantitative Pharmacology in transactions with internal and extern=
al stakeholders.
Who you are:
* Master or PhD in Clinical Sciences related disciplines (Medicine,=
 Physiology, Pharmaceutical Sciences, etc) and strong expertise in Pharmaco=
metrics/biostatistics. Alternatively, degree in Mathematics/Statistics and =
strong experience in clinical development with 3+ years' experience in PKPD=
 Modeling, of which 1+ in BioPharmaceutical Industry and knowledge of PKPD =
M&S input into drug development
* Good command of NONMEM and R is an absolute prerequisite, experie=
nce with MONOLIX is an asset.
* Experience with PsN and Xpose is an asset; as well as experience =
with Clinical Trial Simulation tools, alike for other analytical/modeling/o=
ptimization/presentation software or language, e.g. ADAPT, SAAM II, BERKELE=
Y MADONA. Also experience in writing and using PKPD models, particularly me=
chanistic-models and in developing disease progression models is an asset.
* Fluent in written and oral English and fluency in other European =
languages, particularly French or German, is an asset.
* Strong problem solving skills and ability to analyze complex prob=
* Interest in, and knowledge of, both mathematical and (patho-)phys=
iological aspects of M&S in drug development.
* Enthusiastic, self-motivated and has good communication skills, a=
nd at ease in working in a dynamic matrix organization; is a team-player. C=
ommunicate technical details effectively with scientists and clinicians col=
What we offer: With us, there are always opportunities to break new ground.=
 We empower you to fulfil your ambitions, and our diverse businesses offer =
various career moves to seek new horizons. We trust you with responsibility=
 early on and support you to draw your own career map that is responsive to=
 your aspirations and priorities in life. Join us and bring your curiosity =
to life!
Curious? Apply and find more information at come2merck.com
With best regards,

Akash Khandelwal, Associate Director, Local Head of Pharmacometry (Darmstad=
Pascal Girard, Senior Scientific Director, Global Head of Pharmacometry

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Received on Wed Aug 29 2018 - 11:29:55 EDT

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