Thanks for the confirmation that I wasn't missing something on my end.
For this model, DEFOBS,DEFDOSE works, but I'll remember PCMT in case
it's needed in the future.
On 5/1/2017 3:28 PM, Alison Boeckmann wrote:
> Here's how it looks to me right now.
> I put together a little test case:
> $INPUT ID DOSE=AMT TIME CP=DV WT CMT EVID
> I ran this with a data set in which CMT=2 for both dose and observation
> PREDPP gives me the same error message that you reported:
> DATA REC 1: COMPARTMENT ASSOCIATED WITH THE PREDICTION IS OFF
> NMTRAN makes the assignment of "Default for observations"
> COMPT. NO. FUNCTION INITIAL ON/OFF DOSE DEFAULT
> STATUS ALLOWED ALLOWED FOR DOSE FOR OBS.
> 1 ONE OFF YES NO NO YES
> 2 PKCENT ON YES YES YES NO
> 3 OUTPUT OFF YES NO NO NO
> The PCMT data item is needed with dose records to identify the
> prediction compartment associated with the dose record, and, when PCMT
> is not
> defined, this is defaulting to "Default for observations," which is
> compartment 1,
> which is initially off.
> The DEFAULT FOR OBS compartment should have the attribute "INITIAL ON".
> Your fix is a good one (specify both DEFDOSE and DEFOBS).
> Another fix is to supply the PCMT data item in the data set, and (in my
> case) set PCMT=2
> This is something that can be fixed with a future version of NONMEM (its
> too late for 7.4).
> -- Alison
> On Mon, May 1, 2017, at 09:33 AM, Bill Denney wrote:
>> I have a model with many compartments (42 different compartments
> are defined). It is currently setup this way to future-proof the
> dataset in case we want to combine analyses of many drugs (about
> 20 different drugs with central/peripheral compartments) and
> several endpoints.
>> In the current model, I'm only fitting the PK of one drug, so
> only two of the compartments are enabled: compartments 39 and
> 42. After the IGNORE statement, the data is relatively small with
> 400 records between 16 subjects, and all the data are in
> compartment 39 (the central compartment for the current drug).
>> CMT, EVID, and MDV (along with everything else) is correctly
> specified. When I run the model with CMT 39 defined by:
>> COMP=(PKCENT) ; 39 central PK compartment (ug/mL)
>> the model fails with the error "COMPARTMENT ASSOCIATED WITH THE
> PREDICTION IS OFF" noted for all the dosing rows, but when I
> specify that compartment 39 is the default observation and dose
> compartment (due to IV dosing), the model works.
>> COMP=(PKCENT,DEFOBS,DEFDOSE) ; 39 central PK compartment (ug/mL)
>> I thought that when CMT and EVID are specified, DEFOBS and
> DEFDOSE are not important.
>> Does anyone know why adding DEFOBS and DEFDOSE fixed my model?
> Predictions Logo[http://www.humanpredictions.com/]*William S.
> Denney, PhD*
>> Chief Scientist, Human Predictions LLC
>> This e-mail communication is
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> Alison Boeckmann
Human Predictions Logo <http://www.humanpredictions.com
Chief Scientist, Human Predictions LLC
This e-mail communication is confidential and is intended only for the
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Received on Mon May 01 2017 - 15:32:14 EDT