Re: [NMusers] DEFDOSE/DEFOBS Required for Many Compartments?

From: Bill Denney <wdenney_at_humanpredictions.com>
Date: Mon, 1 May 2017 15:32:14 -0400

Hi Alison,

Thanks for the confirmation that I wasn't missing something on my end.
For this model, DEFOBS,DEFDOSE works, but I'll remember PCMT in case
it's needed in the future.

Thanks,

Bill

On 5/1/2017 3:28 PM, Alison Boeckmann wrote:
> Bill,
> Here's how it looks to me right now.
>
> I put together a little test case:
> $INPUT ID DOSE=AMT TIME CP=DV WT CMT EVID
> $MODEL
> COMP=(One,INITIALOFF,NODOSE)
> COMP=(PKCENT)
>
> I ran this with a data set in which CMT=2 for both dose and observation
> records.
> PREDPP gives me the same error message that you reported:
> DATA REC 1: COMPARTMENT ASSOCIATED WITH THE PREDICTION IS OFF
>
> NMTRAN makes the assignment of "Default for observations"
> inappropriately:
>
> COMPT. NO. FUNCTION INITIAL ON/OFF DOSE DEFAULT
> DEFAULT
> STATUS ALLOWED ALLOWED FOR DOSE FOR OBS.
> 1 ONE OFF YES NO NO YES
> 2 PKCENT ON YES YES YES NO
> 3 OUTPUT OFF YES NO NO NO
>
> The PCMT data item is needed with dose records to identify the
> prediction compartment associated with the dose record, and, when PCMT
> is not
> defined, this is defaulting to "Default for observations," which is
> compartment 1,
> which is initially off.
>
> The DEFAULT FOR OBS compartment should have the attribute "INITIAL ON".
>
> Your fix is a good one (specify both DEFDOSE and DEFOBS).
> Another fix is to supply the PCMT data item in the data set, and (in my
> case) set PCMT=2
>
> This is something that can be fixed with a future version of NONMEM (its
> too late for 7.4).
>
> -- Alison
>
> On Mon, May 1, 2017, at 09:33 AM, Bill Denney wrote:
>> Hi,
>
>> I have a model with many compartments (42 different compartments
> are defined). It is currently setup this way to future-proof the
> dataset in case we want to combine analyses of many drugs (about
> 20 different drugs with central/peripheral compartments) and
> several endpoints.
>
>
>> In the current model, I'm only fitting the PK of one drug, so
> only two of the compartments are enabled: compartments 39 and
> 42. After the IGNORE statement, the data is relatively small with
> 400 records between 16 subjects, and all the data are in
> compartment 39 (the central compartment for the current drug).
>
>
>> CMT, EVID, and MDV (along with everything else) is correctly
> specified. When I run the model with CMT 39 defined by:
>
>
>> COMP=(PKCENT) ; 39 central PK compartment (ug/mL)
>
>> the model fails with the error "COMPARTMENT ASSOCIATED WITH THE
> PREDICTION IS OFF" noted for all the dosing rows, but when I
> specify that compartment 39 is the default observation and dose
> compartment (due to IV dosing), the model works.
>
>
>> COMP=(PKCENT,DEFOBS,DEFDOSE) ; 39 central PK compartment (ug/mL)
>
>> I thought that when CMT and EVID are specified, DEFOBS and
> DEFDOSE are not important.
>
>
>> Does anyone know why adding DEFOBS and DEFDOSE fixed my model?
>
>> Thanks,
>
>> Bill
>
>> Human
> Predictions Logo[http://www.humanpredictions.com/]*William S.
> Denney, PhD*
>> Chief Scientist, Human Predictions LLC
>> +1-617-899-8123
>> wdenney_at_humanpredictions.com
>> This e-mail communication is
> confidential and is intended only for the individual(s) or
> entity named above and others who have been specifically
> authorized to receive it. If you are not the intended
> recipient, please do not read, copy, use or disclose the
> contents of this communication to others. Please notify the
> sender that you have received this e-mail in error by replying
> to the e-mail or by calling +1-617-899-8123. Please then
> delete the e-mail and any copies of it. Thank you.
>
>
>
> --
> Alison Boeckmann
> alisonboeckmann_at_fastmail.fm
>

------------------------------------------------------------------------
Human Predictions Logo <http://www.humanpredictions.com>*William S.
Denney, PhD*
Chief Scientist, Human Predictions LLC
+1-617-899-8123
wdenney_at_humanpredictions.com

This e-mail communication is confidential and is intended only for the
individual(s) or entity named above and others who have been
specifically authorized to receive it. If you are not the intended
recipient, please do not read, copy, use or disclose the contents of
this communication to others. Please notify the sender that you have
received this e-mail in error by replying to the e-mail or by calling
+1-617-899-8123. Please then delete the e-mail and any copies of it.
Thank you.



Received on Mon May 01 2017 - 15:32:14 EDT

This archive was generated by hypermail 2.3.0 : Fri Sep 27 2019 - 16:54:53 EDT