Re: [NMusers] Inherit past calculation of parameter in NONMEM

From: Nick Holford <n.holford_at_auckland.ac.nz>
Date: Wed, 14 Jun 2017 12:04:48 +0200

Tingie,

You can "remember" the value of any variable created in NM-TRAN
abbreviated code. You have to be careful if the variable is a random
effect to always include the else case.

e.g.

IF (NEWIND.LE.1) THEN

CLLAST=? ; some plausible initial value

ENDIF

IF (CL.LE.0) THEN

    CL=CLLAST

ELSE

    CL=CL

ENDIF

CLLAST=CL

Best wishes,
Nick

On 14-Jun-17 11:35, Guo, Tingjie wrote:
>
> Dear NMusers,
>
> Maybe a simple question. I was wondering if there is such
> functionality in NONMEM to inherit the past (e.g. previous row) value
> of parameter calculated with time varying covariates? For instance,
> the CL was determined by a time varying covariate. Calculation CL was
> a negative number in time record 3 due to the covariate value at that
> time point. I would like to use calculation CL in time record 2 as
> instead for time record 3. Pseudocode is somewhat like *IF
> (CL[i].LE.0) CL[i]=CL[i-1]*. Is this possible to implement within
> NONMEM? Thanks in advance.
>
> Warm regards,
>
> Tingjie
>
> *Tingjie Guo I Trainee Research Assistant *
>
> Academic Medical Centre, University of Amsterdam.
>
> VU University Medical Centre, Vrije University Amsterdam.
> Room ZH-7D-172, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
>
> Email: t.guo_at_amc.uva.nl <mailto:t.guo_at_amc.uva.nl> / t.guo_at_vumc.nl
> <mailto:t.guo_at_vumc.nl> Mobile: +31 659738693
>

--
Nick Holford, Professor Clinical Pharmacology
Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A
University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand
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email: n.holford_at_auckland.ac.nz
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http://orcid.org/0000-0002-4031-2514
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Received on Wed Jun 14 2017 - 06:04:48 EDT

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