[NMusers] Inherit past calculation of parameter in NONMEM

From: Guo, Tingjie <t.guo_at_vumc.nl>
Date: Wed, 14 Jun 2017 09:35:02 +0000

Dear NMusers,

Maybe a simple question. I was wondering if there is such functionality in =
NONMEM to inherit the past (e.g. previous row) value of parameter calculate=
d with time varying covariates? For instance, the CL was determined by a ti=
me varying covariate. Calculation CL was a negative number in time record 3=
 due to the covariate value at that time point. I would like to use calcula=
tion CL in time record 2 as instead for time record 3. Pseudocode is somewh=
at like 'IF (CL[i].LE.0) CL[i]=CL[i-1]'. Is this possible to implement wi=
thin NONMEM? Thanks in advance.

Warm regards,

Tingjie Guo I Trainee Research Assistant
Academic Medical Centre, University of Amsterdam.
VU University Medical Centre, Vrije University Amsterdam.
Room ZH-7D-172, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
Email: t.guo_at_amc.uva.nl<mailto:t.guo_at_amc.uva.nl> / t.guo_at_vumc.nl<mailto:t.g=
uo_at_vumc.nl> Mobile: +31 659738693

Received on Wed Jun 14 2017 - 05:35:02 EDT

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