[NMusers] A problem with numerical integration difficulties for a complex model

From: Zhu, Penny <penny.zhu_at_sandoz.com>
Date: Wed, 4 Jan 2017 16:53:14 +0000


Dear all
Sorry to bother you.

I have encountered a problem with a complex model, involve a full TMDD PK m=
odel lined to a complicated multi-compartment PD model. I was only doing a =
simulation based on a published paper so I would prefer not to alter or sim=
plify the model.

The model kept having numerical difficulties no matter how I modify the TOL=
 value (I have changed it from 0 to 6). And I am using ADVAN 8.

Does someone have any idea what else I should try to do to resolve it? Her=
e is the error message. The nonmem code and data are quite long and I coul=
d send you the code/data as files if requested. Many many thanks in advanc=
e for your kind help.

 NUMERICAL DIFFICULTIES WITH INTEGRATION ROUTINE.
 NO. OF REQUIRED SIGNIFICANT DIGITS IN SOLUTION VECTOR
 TO DIFFERENTIAL EQUATIONS, 6, MAY BE TOO LARGE.
 MESSAGE ISSUED FROM SIMULATION STEP


Best


Thank you very much and best regards!

Penny (Peijuan) Zhu, Ph.D.

PD Bio-Pharma CDMA
Sandoz
1N025, 100 College Road West
Princeton, NJ 08540




Received on Wed Jan 04 2017 - 11:53:14 EST

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