[NMusers] Numerical integreaion and change in clearance over time

From: Pavel Belo <nonmem_at_optonline.net>
Date: Tue, 19 Dec 2017 18:15:36 -0500 (EST)

Hello NONMEM Users,
When clearance changes over time, the classic analytical solution for=
the 2-compartment linear model is not correct.  Nevertheless, if the=
change is only ~30%, one can say it is still acceptable.  Time re=
to run an analytical and numerical models is drastically different,
which can be important for decision making.  Did someone  had an=
experience submitting using analytical solution when clearance changes
over time to an agency or a journal?  Can it be acceptable? 

Received on Tue Dec 19 2017 - 18:15:36 EST

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