[NMusers] Helpful Examples in ICON/NONMEM repository

From: Bauer, Robert <Robert.Bauer_at_iconplc.com>
Date: Wed, 25 May 2016 01:55:51 +0000

Dear nmusers:
There are several example problems that have been recently posted at


that may be helpful to you. Please read the readme documents to these fold=

These examples are from working with Matt Hutmacher, and describe how one c=
an model multi-level category problems and incorporate correlations between=
 adjacent data points in a systematic manner using the normal bivariate nor=
mal cumulative distribution function.

These examples are from working with Elodie Plan, demonstrating how to buil=
d hidden Markov models in NONMEM, for Laplace, IMP, and SAEM.

In addition, various utilities for processing NONMEM input and output files=
 are available at


Please read readme_utilities.pdf for information on these utilities.

Of particular note, the file scm.zip in the utilities folder contains the u=
tility objmap than can be used to organize results of a series of stepwise =
covariate model (scm) building problems, map out various relationships and =
catalogue their p-values. Please read objmap.pdf in scm.zip. Also, objmap=
 can be used as a companion to PsN's scm program, and an example is given i=
n the subfolder scm, within folder objmap.

Robert J. Bauer, Ph.D.
Vice President, Pharmacometrics R&D
ICON Early Phase
820 W. Diamond Avenue
Suite 100
Gaithersburg, MD 20878
Office: (215) 616-6428
Mobile: (925) 286-0769
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Received on Tue May 24 2016 - 21:55:51 EDT

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