There are several example problems that have been recently posted at
that may be helpful to you. Please read the readme documents to these fold=
These examples are from working with Matt Hutmacher, and describe how one c=
an model multi-level category problems and incorporate correlations between=
adjacent data points in a systematic manner using the normal bivariate nor=
mal cumulative distribution function.
These examples are from working with Elodie Plan, demonstrating how to buil=
d hidden Markov models in NONMEM, for Laplace, IMP, and SAEM.
In addition, various utilities for processing NONMEM input and output files=
are available at
Please read readme_utilities.pdf for information on these utilities.
Of particular note, the file scm.zip in the utilities folder contains the u=
tility objmap than can be used to organize results of a series of stepwise =
covariate model (scm) building problems, map out various relationships and =
catalogue their p-values. Please read objmap.pdf in scm.zip. Also, objmap=
can be used as a companion to PsN's scm program, and an example is given i=
n the subfolder scm, within folder objmap.
Robert J. Bauer, Ph.D.
Vice President, Pharmacometrics R&D
ICON Early Phase
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Received on Tue May 24 2016 - 21:55:51 EDT