RE: [NMusers] Calculation of half life

From: Stephen Duffull <stephen.duffull_at_otago.ac.nz>
Date: Wed, 30 Mar 2016 17:35:53 +0000

Santosh

Perhaps a more pertinent question is – Why do you want to know half-life?

Steve
………………………………………………………………………………………………………………………..……………………..………………………………………
Stephen Duffull I Professor of Clinical Pharmacy | Dean
Otago Pharmacometrics Group
New Zealand’s National School of Pharmacy | Te Kura Mātauraka Wai-whakaora
University of Otago | Te Whare Wānanga o Otāgo
Dunedin | Ōtepoti
Ph: 64 3 479 5044

Website | www.pharmacometrics.co.nz<http://www.pharmacometrics.co.nz/>



From: owner-nmusers_at_globomaxnm.com [mailto:owner-nmusers_at_globomaxnm.com] On Behalf Of Santosh
Sent: Thursday, 31 March 2016 4:41 a.m.
To: nmusers_at_globomaxnm.com
Subject: [NMusers] Calculation of half life

Dear all,
I am looking for ways to calculate t[1/2,lamda,z] the elimination phase half life, using a 3-compartment model. ADVAN 12 and TRANS6 seems to be a way. However, I am using the intercompartment clearance and volumes based parameterization, e.g. Q3,V3 etc..

half.life = log(2)/gamma

Could anyone please share NONMEM code to compute the half-life based on gamma?

Thanks so much in advance.

Best regards,
Santosh
Received on Wed Mar 30 2016 - 13:35:53 EDT

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