[NMusers] Laplacian, BQL and initial estimates

From: Mark Sale <msale_at_nuventra.com>
Date: Sun, 17 Jul 2016 20:28:00 +0000

Question:

NONMEM has a function to run a grid search to obtain initial estimates for =
THETA. But, when I try to do this with BQL data/Laplacian I get this run ti=
me error message:

0PROGRAM TERMINATED BY OBJ
 WITH INDIVIDUAL 1 ID= 1.00000000000000E+00 DATA REC. 13
 WITH NMPR17, LAPLACIAN ESTIMATION METHOD MUST BE USED


It seems the Laplacian isn't used for the grid search for initial estimates=
 (even though specified in $EST).

any ideas?



Mark Sale M.D.
Vice President, Modeling and Simulation
Nuventra Pharma Sciences, Inc.
2525 Meridian Parkway, Suite 280
Durham, NC 27713
Phone (919)-973-0383
msale_at_nuventra.com<msale_at_kinetigen.com>
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Received on Sun Jul 17 2016 - 16:28:00 EDT

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