[NMusers] Jobs opportunity at Merck (US) Quantitative Pharmacology and Pharmacometrics group

From: Ahamadi Malidi <malidi.ahamadi_at_gmail.com>
Date: Sun, 11 Dec 2016 10:13:46 -0500

Dear all,
The Quantitative Pharmacology and Pharmacometrics (QP2) group at Merck is
now hiring at 3 levels: Senior Scientist, Associate Principal Scientist,
and Principal Scientist. Qualified candidates will be hired at the level
commensurate with their experience. Merck sponsors work visas for qualified
candidates. Please find below the job description.

*Location*: West Point, PA; Upper Gwynedd, PA; Kenilworth, NJ; Rahway, NJ;
Boston, MA.

*Online application: *please visit http://www.merck.com/careers/

   - Senior Scientist, R3 (QUA005204)
   - Associate Principal Scientist, R4 (QUA005203)
   - Principal Scientist, R5 (QUA005218)

*Senior Scientist, R3 (QUA005204) *
Senior scientists in Quantitative Pharmacology and Pharmacometrics (QP2)
apply quantitative approaches to develop and implement translational PK/PD
strategies, characterize clinical pharmacokinetics and pharmacodynamics of
new chemical entities, and inform dose selection and go/no-go decisions.
Senior Scientists work in collaboration with more experienced scientists,
and are expected to develop expertise in one or more scientific areas
necessary to performing primary responsibilities including:

   - Being or supporting the lead representative for QP2 on drug/vaccine
   development teams
   - Framing critical drug development questions for optimizing model-based
   development
   - Developing and executing translational PK/PD approaches, population
   pharmacokinetic models, exposure-response and stratification biomarker
   models, QSP and disease progression models, clinical trial design via
   outcome/enrollment modeling and simulation, comparator modeling,
   absorption/biopharmaceutical modeling, clinical utility index modeling, =
and
   other model-based analyses.

Senior Scientists are expected to develop a comprehensive understanding of
global regulatory expectations for small molecules, biologics, and/or
vaccines, including support for regulatory documents (INDs, CSRs, CTDs),
and agency interactions. The Senior Scientist is a talented modeler and
quantitative drug developer with a strong, integrated understanding of the
strategic elements of drug discovery and development, and leads the
combined efforts of QP2 & the wider Department of Pharmacokinetics,
Pharmacodynamics and Drug Metabolism (PPDM). In addition, Senior
Scientists demonstrate leadership, communication, and collaboration with
QP2 leadership and key functional areas to create an aligned, quantitative
framework decisions of drug development teams.

*Education Minimum Requirement: *

   - Ph.D. or an MS with a minimum 4 years years of experience in a similar
   role in pharmaceutical drug development or academia and with a record of
   increasing responsibility and independence.
   - Educational background in biopharmaceutics, pharmaceutical sciences,
   pharmacometrics, mathematics, statistics/biostatistics , computational
   biology/chemistry, chemical/biomedical engineering, or a related field=
.

*Preferred Experience and Skills:*

   - Proficiency in quantitative analyses, modeling and simulation, and
   data exploration.
   - Experience in noncompartmental analyses and in modeling and simulation
   of PK, population PK, and PK/PD.
   - Familiarity with nonlinear mixed-effect modeling and the use of
   standard pharmacometric software (e.g. NONMEM, R, Matlab, etc.).
   - Solid proficiencies in written and verbal communication, interpersonal
   skills, problem scoping and planning, and the ability to participate in
   interdisciplinary teams.



*Associate Principal Scientist, R4 (QUA005203)*
Associate Principal Scientists in Quantitative Pharmacology and
Pharmacometrics (QP2) apply quantitative approaches to develop and
implement translational PK/PD strategies, characterize clinical
pharmacokinetics and pharmacodynamics of new chemical entities, and inform
dose selection and go/no-go decisions. Associate Principal Scientists
perform job duties independently with minimal supervision, are capable of
supporting or leading QP2 efforts on drug/vaccine development programs, and
of authoring strategic documents. Associate Principal Scientists are
expected to have or be developing expertise in several scientific key areas
for QP2, including:

   - Serving as an expert representative for QP2 on drug/vaccine
   development teams
   - Framing critical drug development questions for optimizing model-based
   development
   - Developing and executing translational PK/PD models, population
   pharmacokinetic models, exposure-response (PK/PD) models, stratification
   biomarker models, QSP and disease progression models, clinical trial des=
ign
   via outcome/enrollment modeling and simulation, comparator modeling,
   absorption/biopharmaceutical modeling, clinical utility index modeling, =
and
   other model-based analyses
   - Maintaining a comprehensive understanding of global regulatory
   expectations for small molecules and biologics, authoring regulatory
   documents (INDs, CSRs, CTDs), and representing QP2 at regulatory meeting=
s


The Associate Principal Scientist is a skilled modeler and a quantitative
drug/vaccine developer, with a strong, integrated understanding of the
strategic elements of drug discovery and development, and leads the
combined efforts of QP2 & the wider Department of Pharmacokinetics,
Pharmacodynamics and Drug Metabolism (PPDM). In addition to the
responsibilities described above, Associate Principal Scientists
demonstrate excellent leadership and communication, and collaborate with
PPDM and other functional area leaders to create an aligned, quantitative
framework impacting strategies and decisions of drug development teams, and
to provide scientific/strategic leadership and influence on drug
development teams.

 *Education Minimum Requirement:*

   - Educational background in biopharmaceutics, pharmaceutical sciences,
   pharmacometrics, mathematics, statistics/biostatistics , computational
   biology/chemistry, chemical/biomedical engineering, or a related field=
.
   - Ph.D. with a minimum 3 years OR an MS with a minimum 7 years of
   experience in a similar role in pharmaceutical drug development or
   academia, with a record of increasing responsibility and independence.


*Preferred Experience and Skills:*

   - An excellent record of increasing responsibility, independence, and
   demonstrated impact in driving drug development decisions through
   application of model-based approaches in the pharmaceutical industry.
   - Strong skills in experimental design, mathematical problem solving,
   critical data analysis/interpretation, statistics, and hands-on computer
   modeling skills.
   - Proficiency with the use of one or more of the following software
   packages: NONMEM, R, Matlab, SPlus, WinNonLin, Phoenix. Experience with
   NONMEM and with the statistical software package R is strongly preferred=
.
   - Solid proficiencies in written and verbal communication, interpersonal
   skills, problem scoping and planning, and the ability to participate in =
and
   lead interdisciplinary teams, are critical.



*Principal Scientist, R5 (QUA005218)*
Principal Scientists in Quantitative Pharmacology and Pharmacometrics (QP2)
apply quantitative approaches to develop and implement translational PK/PD
strategies, characterize clinical pharmacokinetics and pharmacodynamics of
new chemical entities, and inform dose selection and go/no-go decisions.
Principal Scientists perform job duties independently with minimal
supervision, and mentor others to develop similar capabilities. They lead
QP2 efforts on drug development programs, and author strategic documents.
Principal Scientists are expected to have or be developing expertise in
several scientific key areas for QP2, including:

   - Serving as an expert representative for QP2 on drug/vaccine
   development teams
   - Applying functional area knowledge to frame critical drug development
   questions for optimizing model-based drug development
   - Strong ability to develop/execute and guide/mentor others on
   translational PK/PD models, population pharmacokinetic models,
   exposure-response (PK/PD) models, stratification biomarker models, QSP a=
nd
   disease progression models, clinical trial design via outcome/enrollment
   modeling and simulation, comparator modeling, absorption/biopharmaceutic=
al
   modeling, clinical utility index modeling, and other model-based analyse=
s
   - Maintaining, and helping others develop and maintain, a comprehensive
   understanding of global regulatory expectations for small molecules and
   biologics, authoring regulatory documents (INDs, CSRs, CTDs), and
   representing QP2 at regulatory meetings
   - Scientific and/or supervisory oversight of a group of scientists


The Principal Scientist is a skilled modeler and a quantitative
drug/vaccine developer, with a strong, integrated understanding of the
strategic elements of drug discovery and development, and leads the
combined efforts of QP2 & the wider Department of Pharmacokinetics,
Pharmacodynamics and Drug Metabolism (PPDM). In addition to the
responsibilities described above, Principal Scientists demonstrate
outstanding leadership, communication, and collaboration with key
functional areas to create an aligned, quantitative framework impacting
strategies and decisions of drug development teams, and to provide
scientific/strategic leadership and influence on drug development teams.


*Education Minimum Requirement: *

   - Educational background in biopharmaceutics, pharmaceutical sciences,
   pharmacometrics, mathematics, statistics/biostatistics, computational
   biology/chemistry, chemical/biomedical engineering, or a related field.
   - Ph.D. with a minimum 7 years OR an MS with a minimum 11 years and
   with a record of increasing responsibility and independence.


*Preferred Experience and Skills:*

   - An exemplary record of increasing responsibility, independence, and
   demonstrated impact in driving drug development decisions through
   application of model-based approaches in the pharmaceutical industry.
   - Strong skills in experimental design, mathematical problem solving,
   critical data analysis/interpretation, statistics, and hands-on computer
   modeling skills.
   - Proficiency with the use of one or more of the following software
   packages: NONMEM, R, Matlab, SPlus, WinNonLin, Phoenix. Experience with
   NONMEM and with the statistical software package R is strongly preferred=
.
   - Solid proficiencies in written and verbal communication, interpersonal
   skills, problem scoping and planning, and the ability to participate in =
and
   lead interdisciplinary teams, are critical.
   - Experience overseeing the work of other PhD scientists is desirable.


Merck Culture: Merck & Co., Inc. Kenilworth, NJ USA, is known as MSD
outside the United States and Canada. Our business is preserving and
improving human life. We also work to improve animal health. All of our
actions must be measured by our success in achieving these goals. We value,
above all, our ability to serve everyone who can benefit from the
appropriate use of our products and services, thereby providing lasting
consumer satisfaction. Today, we are building a new kind of healthcare
company – one that is ready to help create a healthier future for a=
ll of
us. Our ability to excel depends on the integrity, knowledge, imagination,
skill, diversity and teamwork of an individual like you. To this end, we
strive to create an environment of mutual respect, encouragement and
teamwork. As part of our global team, you’ll have the opportunity t=
o
collaborate with talented and dedicated colleagues while developing and
expanding your career.


Regards,
Malidi

--
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web:https://www.linkedin.com/in/malidi-ahamadi-40834b11
<http://www.maths.leeds.ac.uk/~malidi/>
"In the end, we will remember not the words
of our enemies, but the silence of our
friends." Martin Luther King, Jr.
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Received on Sun Dec 11 2016 - 10:13:46 EST

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