Re: [NMusers] Time varying volume of distribution implementation

From: Graaf, P.H. van der <p.vandergraaf_at_lacdr.leidenuniv.nl>
Date: Sat, 23 Apr 2016 07:54:42 +0000

Natal van Riel presented on this topic in the context of large systems mode=
ls at a recent QSP meeting in Basel, see for example
http://www.ncbi.nlm.nih.gov/pubmed/23935478
Best,
Piet

Piet H. van der Graaf, PharmD PhD
Professor of Systems Pharmacology
Leiden Academic Centre for Drug Research (LACDR)
2333 CC Leiden
The Netherlands
From: M Jamei
Sent: Saturday, 23 April 2016 08:30
To: Thorsten Lehr
Cc: nmusers_at_globomaxnm.com
Subject: Re: [NMusers] Time varying volume of distribution implementation


Hi Thorsten

We have done this in both paediatrics and pregnancy and you may find the fo=
llowing paper useful.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012043/
Changes in individual drug-independent system parameters during virtual pae=
diatric pharmacokinetic trials: introducing time-varying physiology into a =
paediatric PBPK model.
Abduljalil K, et al. AAPS J. 2014.

Regards
Masoud

On 22 Apr 2016, at 22:34, Thorsten Lehr <thorsten.lehr_at_mx.uni-saarland.de<m=
ailto:thorsten.lehr_at_mx.uni-saarland.de>> wrote:


Dear NMusers,

I'm modeling a compound where body weight has a known impact on the volume =
of distribution. This compound is investigated in pregnant women over a lon=
g period (from gestational age of 8 weeks until they give birth). Consequen=
tly, the body weight changes over time and I have a decent formula to descr=
ibe the individual body weight change. The PK model has to be coded by ODEs=
. Does anyone has experience how to integrate a time varying volume of dist=
ribution if differential equations are used?

Best regards

Thorsten

--

Thorsten Lehr, PhD
Junior Professor of Clinical Pharmacy
Saarland University
Campus C2 2
66123 Saarbrücken
Germany

Office: +49/681/302-70255
Mobile: +49/151/22739489
thorsten.lehr_at_mx.uni-saarland.de<mailto:thorsten.lehr_at_mx.uni-saarland.de>
www.clinicalpharmacy.me<http://www.clinicalpharmacy.me>

Received on Sat Apr 23 2016 - 03:54:42 EDT

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