[NMusers] Re: Error in table step

From: Mark Sale <msale_at_nuventra.com>
Date: Mon, 28 Sep 2015 10:35:59 +0000

Rik,

 Thanks, that is basically where I'm at now, Leonid Gibiansky and Brian Sad=
ler had some helpful suggestions, involving using FNLETA=0 or 2, so that =
it used the ETAs from the estimation for the tables (which I don't understa=
nd why that didn't work, why estimation was fine, but crashed on tables). =
Tried FOCE, IMPMAP as well as SAEM. I did try removing the offending subje=
cts, but just had the same problem with another (ultimately removed nearly =
1/3 of the data, still had the error). So, ended up just going back to a s=
impler model.


thank

Mark


Mark Sale M.D.
Vice President, Modeling and Simulation
Nuventra, Inc. ™
2525 Meridian Parkway, Suite 280
Research Triangle Park, NC 27713
Office (919)-973-0383
msale_at_nuventra.com<msale_at_kinetigen.com>
www.nuventra.com<http://www.nuventra.com>



Empower your Pipeline

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hments, if any) may be privileged and confidential and is intended only for=
 the recipient(s) listed above. Any review, use, disclosure, distribution o=
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________________________________
From: owner-nmusers_at_globomaxnm.com <owner-nmusers_at_globomaxnm.com> on behalf=
 of Rik Schoemaker <rik.schoemaker_at_occams.eu>
Sent: Monday, September 28, 2015 4:07 AM
To: nmusers_at_globomaxnm.com
Subject: [NMusers] RE: Error in table step


Dear Mark,



I've very recently run into the same issue and in my case removing the indi=
vidual didn't change one bit; it just came up with a new individual. I also=
 implemented all the ususal checks with no avail. In my case I'm convinced =
it had to do with an over-parameterized model where fixing the IIV of an il=
l-defined parameter made the error go away, or at least most of the times w=
ith appropriate starting values. It did make the OFV increase substantially=
 but that's the price I was willing to pay… (FOCE and likelihood estimati=
on by the way, so indeed not specific to SAEM).



Good luck!



Rik Schoemaker, PhD

Occams BV
Malandolaan 10
1187 HE Amstelveen
The Netherlands

www.occams.eu<http://www.occams.eu/>

+31 20 441 6410
rik.schoemaker_at_occams.eu<mailto:rik.schoemaker_at_occams.eu>



[cid:image001.png_at_01D04614.F6072CE0]







From: owner-nmusers_at_globomaxnm.com [mailto:owner-nmusers_at_globomaxnm.com] On=
 Behalf Of Mark Sale
Sent: 27 September 2015 15:29
To: nmusers_at_globomaxnm.com
Subject: [NMusers] Error in table step



Dear colleagues:



I have a very large model (lots of ODEs, lots of data, long duration), runn=
ing parallel across several machines, using SAEM. Runs reasonably well. B=
ut, fails the $TABLE with this error:

0PROGRAM TERMINATED BY FNLETA

0PRED EXIT CODE = 1

0INDIVIDUAL NO. 3 ID= 5.10000000000000E+01 (WITHIN-INDIVIDUAL) =
DATA REC NO. 1

 THETA=

  0.00E+00 1.19E+00 2.59E-01 5.68E+00 2.64E-01 5.69E+00 2.35E+0=
0 4.17E-01 4.20E-04 6.50E-01

  3.98E-01 1.86E-01 -3.50E-01 -2.09E-01 -1.87E+00 2.09E-01 1.85E-0=
1 -1.90E-01 1.30E+00 4.82E-01

  0.00E+00 9.54E-01 1.34E+03 1.19E+00 3.44E-01 1.78E+03

 OCCURS DURING SEARCH FOR ETA AT INITIAL VALUE, ETA=0

 F OR DERIVATIVE RETURNED BY PRED IS INFINITE (INF) OR NOT A NUMBER (NAN).

0PROGRAM TERMINATED BY FNLETA

 MESSAGE ISSUED FROM TABLE STEP



All the THETA values of 0.00 are fixed to that value. All the other values =
are very reasonable.



So, I don't get any tables, can't to a VPC etc. I've tried running FOCE, n=
o better. Tried error checking that F is always positive, tried EXIT if F =
is very small, I have the NOABORT option set (but I don't think that is rel=
evant in the $TABLE step).



I assume it is crashing calculating the conditional ETAs (don't know why it=
 does OK in estimation). PRDERR only has the small number of error from th=
e estimation



Anyone seen this error, any suggestions on how to get rid of it (other than=
 removeing subject 51)?



Mark







Mark Sale M.D.

Vice President, Modeling and Simulation

Nuventra, Inc. ™

2525 Meridian Parkway, Suite 280

Research Triangle Park, NC 27713

Office (919)-973-0383

msale_at_nuventra.com<msale_at_kinetigen.com>

www.nuventra.com<http://www.nuventra.com>







Empower your Pipeline



CONFIDENTIALITY NOTICE The information in this transmittal (including attac=
hments, if any) may be privileged and confidential and is intended only for=
 the recipient(s) listed above. Any review, use, disclosure, distribution o=
r copying of this transmittal, in any form, is prohibited except by or on b=
ehalf of the intended recipient(s). If you have received this transmittal i=
n error, please notify me immediately by reply email and destroy all copies=
 of the transmittal.



Received on Mon Sep 28 2015 - 06:35:59 EDT

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