[NMusers] RE: Error in table step

From: Rik Schoemaker <rik.schoemaker_at_occams.eu>
Date: Mon, 28 Sep 2015 08:07:34 +0000

Dear Mark,

I've very recently run into the same issue and in my case removing the indi=
vidual didn't change one bit; it just came up with a new individual. I also=
 implemented all the ususal checks with no avail. In my case I'm convinced =
it had to do with an over-parameterized model where fixing the IIV of an il=
l-defined parameter made the error go away, or at least most of the times w=
ith appropriate starting values. It did make the OFV increase substantially=
 but that's the price I was willing to pay... (FOCE and likelihood estimati=
on by the way, so indeed not specific to SAEM).

Good luck!

Rik Schoemaker, PhD
Occams BV
Malandolaan 10
1187 HE Amstelveen
The Netherlands
www.occams.eu<http://www.occams.eu/>
+31 20 441 6410
rik.schoemaker_at_occams.eu<mailto:rik.schoemaker_at_occams.eu>

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From: owner-nmusers_at_globomaxnm.com [mailto:owner-nmusers_at_globomaxnm.com] On=
 Behalf Of Mark Sale
Sent: 27 September 2015 15:29
To: nmusers_at_globomaxnm.com
Subject: [NMusers] Error in table step


Dear colleagues:



I have a very large model (lots of ODEs, lots of data, long duration), runn=
ing parallel across several machines, using SAEM. Runs reasonably well. B=
ut, fails the $TABLE with this error:
0PROGRAM TERMINATED BY FNLETA
0PRED EXIT CODE = 1
0INDIVIDUAL NO. 3 ID= 5.10000000000000E+01 (WITHIN-INDIVIDUAL) =
DATA REC NO. 1
 THETA=
  0.00E+00 1.19E+00 2.59E-01 5.68E+00 2.64E-01 5.69E+00 2.35E+0=
0 4.17E-01 4.20E-04 6.50E-01
  3.98E-01 1.86E-01 -3.50E-01 -2.09E-01 -1.87E+00 2.09E-01 1.85E-0=
1 -1.90E-01 1.30E+00 4.82E-01
  0.00E+00 9.54E-01 1.34E+03 1.19E+00 3.44E-01 1.78E+03
 OCCURS DURING SEARCH FOR ETA AT INITIAL VALUE, ETA=0
 F OR DERIVATIVE RETURNED BY PRED IS INFINITE (INF) OR NOT A NUMBER (NAN).
0PROGRAM TERMINATED BY FNLETA
 MESSAGE ISSUED FROM TABLE STEP


All the THETA values of 0.00 are fixed to that value. All the other values =
are very reasonable.



So, I don't get any tables, can't to a VPC etc. I've tried running FOCE, n=
o better. Tried error checking that F is always positive, tried EXIT if F =
is very small, I have the NOABORT option set (but I don't think that is rel=
evant in the $TABLE step).



I assume it is crashing calculating the conditional ETAs (don't know why it=
 does OK in estimation). PRDERR only has the small number of error from th=
e estimation



Anyone seen this error, any suggestions on how to get rid of it (other than=
 removeing subject 51)?



Mark






Mark Sale M.D.
Vice President, Modeling and Simulation
Nuventra, Inc. (tm)
2525 Meridian Parkway, Suite 280
Research Triangle Park, NC 27713
Office (919)-973-0383
msale_at_nuventra.com<msale_at_kinetigen.com>
www.nuventra.com<http://www.nuventra.com>



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Received on Mon Sep 28 2015 - 04:07:34 EDT

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