Re: [NMusers] Error in table step

From: Leonid Gibiansky <lgibiansky_at_quantpharm.com>
Date: Sun, 27 Sep 2015 10:27:18 -0400

Hi Mark
I see it quite often. One idea is to clean the data: outliers can cause
it. Another is to increase precision of computations (TOL, SIGL=15). You
can do it using MSF (not to re-run everything). I remember there was an
advice to use MCETA but I have not tried it. To get at least some values
you can use FNLETA=0; then Nonmem will use estimation step etas to
compute individual predictions.
Leonid

--------------------------------------
Leonid Gibiansky, Ph.D.
President, QuantPharm LLC
web: www.quantpharm.com
e-mail: LGibiansky at quantpharm.com
tel: (301) 767 5566



On 9/27/2015 9:29 AM, Mark Sale wrote:
> Dear colleagues:
>
>
> I have a very large model (lots of ODEs, lots of data, long duration),
> running parallel across several machines, using SAEM. Runs reasonably
> well. But, fails the $TABLE with this error:
>
> 0PROGRAM TERMINATED BY FNLETA
> 0PRED EXIT CODE = 1
> 0INDIVIDUAL NO. 3 ID= 5.10000000000000E+01 (WITHIN-INDIVIDUAL)
> DATA REC NO. 1
> THETA=
> 0.00E+00 1.19E+00 2.59E-01 5.68E+00 2.64E-01 5.69E+00
> 2.35E+00 4.17E-01 4.20E-04 6.50E-01
> 3.98E-01 1.86E-01 -3.50E-01 -2.09E-01 -1.87E+00 2.09E-01
> 1.85E-01 -1.90E-01 1.30E+00 4.82E-01
> 0.00E+00 9.54E-01 1.34E+03 1.19E+00 3.44E-01 1.78E+03
> OCCURS DURING SEARCH FOR ETA AT INITIAL VALUE, ETA=0
> F OR DERIVATIVE RETURNED BY PRED IS INFINITE (INF) OR NOT A NUMBER (NAN).
> 0PROGRAM TERMINATED BY FNLETA
> MESSAGE ISSUED FROM TABLE STEP
>
> All the THETA values of 0.00 are fixed to that value. All the other
> values are very reasonable.
>
>
> So, I don't get any tables, can't to a VPC etc. I've tried running
> FOCE, no better. Tried error checking that F is always positive, tried
> EXIT if F is very small, I have the NOABORT option set (but I don't
> think that is relevant in the $TABLE step).
>
>
> I assume it is crashing calculating the conditional ETAs (don't know why
> it does OK in estimation). PRDERR only has the small number of error
> from the estimation
>
>
> Anyone seen this error, any suggestions on how to get rid of it (other
> than removeing subject 51)?
>
>
> Mark
>
>
>
>
> Mark Sale M.D.
>
> Vice President, Modeling and Simulation
>
> Nuventra, Inc. ™
>
> 2525 Meridian Parkway, Suite 280
>
> Research Triangle Park, NC 27713
>
> Office (919)-973-0383
>
> msale_at_nuventra.com <msale_at_kinetigen.com>
>
> www.nuventra.com <http://www.nuventra.com>
>
>
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> ------------------------------------------------------------------------
> *From:* owner-nmusers_at_globomaxnm.com <owner-nmusers_at_globomaxnm.com> on
> behalf of nonmem <nonmem_at_optonline.net>
> *Sent:* Wednesday, September 23, 2015 6:47 PM
> *To:* Spilker, Mary; nmusers_at_globomaxnm.com
> *Subject:* RE: [NMusers] PK-PD Modeling position available (Pfizer
> Location: La Jolla, CA)
> Dear Mary, l may be over qualified for the position. My current
> position is equal to associate director level at Regeneron and my
> experience exceeds 2 years significantly. Thank you, Pavel
>
>
>
> Sent via the Samsung Galaxy S® 5 ACTIVE™, an AT&T 4G LTE smartphone
>
>
> -------- Original message --------
> From: "Spilker, Mary" <Mary.Spilker_at_pfizer.com>
> Date: 09/23/2015 12:49 PM (GMT-05:00)
> To: nmusers_at_globomaxnm.com
> Subject: [NMusers] PK-PD Modeling position available (Pfizer Location:
> La Jolla, CA)
>
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Received on Sun Sep 27 2015 - 10:27:18 EDT

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