[NMusers] RE: Error in table step

From: Sadler, Brian <Brian.Sadler_at_iconplc.com>
Date: Sun, 27 Sep 2015 14:22:20 +0000

Hi Mark,

I encountered this same problem recently and wound up using $MSFI and FNLE=
TA=2 in the $EST statement. This reads values from the previously created=
 MSF file and skips $EST and the post hoc evaluation of the etas at the mod=
e of the posterior density (see caveat on page 60 of the v7.3 manual). None=
theless, this will allow $TABLE to generate output.

Cheers... Brian

From: owner-nmusers_at_globomaxnm.com [mailto:owner-nmusers_at_globomaxnm.com] On=
 Behalf Of Mark Sale
Sent: Sunday, September 27, 2015 9:29 AM
To: nmusers_at_globomaxnm.com
Subject: [NMusers] Error in table step


Dear colleagues:



I have a very large model (lots of ODEs, lots of data, long duration), runn=
ing parallel across several machines, using SAEM. Runs reasonably well. B=
ut, fails the $TABLE with this error:
0PROGRAM TERMINATED BY FNLETA
0PRED EXIT CODE = 1
0INDIVIDUAL NO. 3 ID= 5.10000000000000E+01 (WITHIN-INDIVIDUAL) =
DATA REC NO. 1
 THETA=
  0.00E+00 1.19E+00 2.59E-01 5.68E+00 2.64E-01 5.69E+00 2.35E+0=
0 4.17E-01 4.20E-04 6.50E-01
  3.98E-01 1.86E-01 -3.50E-01 -2.09E-01 -1.87E+00 2.09E-01 1.85E-0=
1 -1.90E-01 1.30E+00 4.82E-01
  0.00E+00 9.54E-01 1.34E+03 1.19E+00 3.44E-01 1.78E+03
 OCCURS DURING SEARCH FOR ETA AT INITIAL VALUE, ETA=0
 F OR DERIVATIVE RETURNED BY PRED IS INFINITE (INF) OR NOT A NUMBER (NAN).
0PROGRAM TERMINATED BY FNLETA
 MESSAGE ISSUED FROM TABLE STEP


All the THETA values of 0.00 are fixed to that value. All the other values =
are very reasonable.



So, I don't get any tables, can't to a VPC etc. I've tried running FOCE, n=
o better. Tried error checking that F is always positive, tried EXIT if F =
is very small, I have the NOABORT option set (but I don't think that is rel=
evant in the $TABLE step).



I assume it is crashing calculating the conditional ETAs (don't know why it=
 does OK in estimation). PRDERR only has the small number of error from th=
e estimation



Anyone seen this error, any suggestions on how to get rid of it (other than=
 removeing subject 51)?



Mark






Mark Sale M.D.
Vice President, Modeling and Simulation
Nuventra, Inc. (tm)
2525 Meridian Parkway, Suite 280
Research Triangle Park, NC 27713
Office (919)-973-0383
msale_at_nuventra.com<msale_at_kinetigen.com>
www.nuventra.com<http://www.nuventra.com>



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________________________________
From: owner-nmusers_at_globomaxnm.com<mailto:owner-nmusers_at_globomaxnm.com> <ow=
ner-nmusers_at_globomaxnm.com<mailto:owner-nmusers_at_globomaxnm.com>> on behalf =
of nonmem <nonmem_at_optonline.net<mailto:nonmem_at_optonline.net>>
Sent: Wednesday, September 23, 2015 6:47 PM
To: Spilker, Mary; nmusers_at_globomaxnm.com<mailto:nmusers_at_globomaxnm.com>
Subject: RE: [NMusers] PK-PD Modeling position available (Pfizer Location: =
La Jolla, CA)

Dear Mary, l may be over qualified for the position. My current position i=
s equal to associate director level at Regeneron and my experience exceeds =
2 years significantly. Thank you, Pavel



Sent via the Samsung Galaxy S(r) 5 ACTIVE(tm), an AT&T 4G LTE smartphone


-------- Original message --------
From: "Spilker, Mary" <Mary.Spilker_at_pfizer.com<mailto:Mary.Spilker_at_pfizer.c=
om>>
Date: 09/23/2015 12:49 PM (GMT-05:00)
To: nmusers_at_globomaxnm.com<mailto:nmusers_at_globomaxnm.com>
Subject: [NMusers] PK-PD Modeling position available (Pfizer Location: La J=
olla, CA)
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Received on Sun Sep 27 2015 - 10:22:20 EDT

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