[NMusers] Is “DOSE=0” accepted by NONMEM?

From: Zheng Liu <Zheng.Liu_at_rch.org.au>
Date: Mon, 7 Sep 2015 06:30:11 +0000

Dear NONMEM users,



I have a group of patients, whose plasma drug levels are measured and known=
 at time=0 (no further drug is given to the patients afterwards.). I try =
to know, after how long time the drug will be completely cleared out from t=
hese patients. Naturally I used NONMEM to fit the patients' V and CL, in or=
der to get plasma concentration change profile.


However seems NONMEM only accepts DOSE is a positive number. If DOSE=0, N=
ONMEM can't perform the fitting. Can anyone kindly give me some suggestions=
 to solve this problem? Thanks a lot in advance!



PTID DV AMT time EVID
2 . 0
        0 1
2 6.8 0 0 0
2 1.1 0 3 0
2 0 0 6 0
3 . 0 0 1
3 1.08 0 0 0
3 0.16 0 3 0
3 0.03 0 6 0
3 0 0 9 0



Zheng


Received on Mon Sep 07 2015 - 02:30:11 EDT

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