Re: [NMusers] RE: Estimation of ke0 from raw data

From: Jeroen Elassaiss-Schaap (PD-value B.V.) <"Jeroen>
Date: Sat, 5 Sep 2015 22:23:18 +0200

Hi Jos,

Leonid has a post on it from some time ago, where he shows code to do
indeed linear interpolation.
see http://www.cognigencorp.com/nonmem/current/2008-January/4167.html

See also some older thread that discusses more possibilities:
http://www.cognigencorp.com/nonmem/nm/99sep241996.html

Anyway, it comes down to storing the current and previous concentration,
calculating the slope and with these parameters, interpolate in the $DES
block with T for time.

Hope this helps,
Jeroen

--

http://pd-value.com
jeroen_at_pd-value.com
_at_PD_value
+31 6 23118438
-- More value out of your data!


On 09/05/2015 08:44 PM, Lommerse, JPM (Jos) wrote:
>
> Dear Samer,
>
>
>
> Thank you for the reference.
>
> However, the method of Fuseau assumes
>
> that a mathematical description for
>
> the PK curve is available.
>
>
>
> I would like to do without such a PK description
>
> and directly use the PK observations, e.g. applying
>
> linear interpolation between the PK data points.
>
> Would that be feasible?
>
>
>
> Thanks, Jos
>
>
>
> *From:*Samer Mouksassi [mailto:Samer.Mouksassi_at_certara.com]
> *Sent:* Saturday, September 05, 2015 8:34 PM
> *To:* Lommerse, JPM (Jos); nmusers_at_globomaxnm.com
> *Subject:* RE: Estimation of ke0 from raw data
>
>
>
>
>
> Dear Jos,
>
> Please have a look at the algorithm detailed in the appendix of this
> publication:
>
> Fuseau E, Sheiner LB.
>
> Simultaneous modeling of pharmacokinetics and pharmacodynamics with a
> nonparametric pharmacodynamic model.
>
> Clin Pharmacol Ther. 1984 Jun;35(6):733-41.
>
> Regards,
>
> Samer
>
>
>
>
>
> *From:* owner-nmusers_at_globomaxnm.com
> <mailto:owner-nmusers_at_globomaxnm.com>
> [mailto:owner-nmusers_at_globomaxnm.com] *On Behalf Of *Lommerse, JPM (Jos)
> *Sent:* Saturday, September 5, 2015 1:44 PM
> *To:* nmusers_at_globomaxnm.com <mailto:nmusers_at_globomaxnm.com>
> *Subject:* [NMusers] Estimation of ke0 from raw data
>
>
>
> Hi,
>
>
>
> I have a data set containing PK concentrations and PD effect.
>
> When plotting PD as a function of PD a clear anti-clockwise hysteresis
>
> plot appears.
>
> I would like to get a (rough) estimate of the PD time delay w.r.t. the
> PK without
>
> using a compartmental description for the observed PK, even not using
>
> a polynomal function that fits the PK. The assumption I make is that
>
> all PD delay can be explained by the delay through an effect compartment.
>
> I am wondering if methods exist that solely use the raw data to
>
> calculate such time delays.
>
>
>
> Thank you for any comment/suggestion,
>
>
>
> Jos
>
>
>
> *Jos Lommerse*
>
> Modeler Consultant
>
> /Quantitative Solutions BV/
>
> /Molenweg 79/
>
> /5349 AC Oss/
>
> /The Netherlands/
>
> jlommerse_at_wequantify.com <mailto:jlommerse_at_wequantify.com>
>
> +31 412 211102
>
>
>
>
>
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Received on Sat Sep 05 2015 - 16:23:18 EDT

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