Re: [NMusers] Estimation of ke0 from raw data

From: Mukul <mukul.minocha_at_gmail.com>
Date: Sat, 5 Sep 2015 14:27:26 -0400

Hi Jos,

Why not try the indirect response model instead? The fixed effects are more i=
nterpretable pharmacologically than just using Ke0.
The initial estimate of the first order rate constant of degradation (kout) o=
f response could be the slope of the decline of the response when plotted wi=
th time.

You can read more in detail as there is lot of literature if you are not fam=
iliar with these models.

Best

Mukul Minocha


> On 05-Sep-2015, at 13:43, Lommerse, JPM (Jos) <jos.lommerse_at_merck.com> wro=
te:
>
> Hi,
>
> I have a data set containing PK concentrations and PD effect.
> When plotting PD as a function of PD a clear anti-clockwise hysteresis
> plot appears.
> I would like to get a (rough) estimate of the PD time delay w.r.t. the PK w=
ithout
> using a compartmental description for the observed PK, even not using
> a polynomal function that fits the PK. The assumption I make is that
> all PD delay can be explained by the delay through an effect compartment.
> I am wondering if methods exist that solely use the raw data to
> calculate such time delays.
>
> Thank you for any comment/suggestion,
>
> Jos
>
> Jos Lommerse
> Modeler Consultant
> Quantitative Solutions BV
> Molenweg 79
> 5349 AC Oss
> The Netherlands
> jlommerse_at_wequantify.com
> +31 412 211102
>
>
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Received on Sat Sep 05 2015 - 14:27:26 EDT

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