[NMusers] Advanced course on Pharmacometrics

From: roberto gomeni <roberto.gomeni_at_pharmacometrica.com>
Date: Wed, 2 Sep 2015 08:03:41 +0200

Dear NMusers,

 

This is the second announcement for the:

 

Advanced course on Pharmacometrics

16 - 18 Nov. 2015

Château de Longcol, Longcol, La Fouillade (France)

 

This is a 4-day course designed to develop and implement a
drug-disease-trial model strategy for optimizing the drug development
process using convolution-based methodologies and optimal design =
strategies.

 

Course outline

* Determine the modelling strategy for characterizing the in-vivo
absorption processes for extended release formulations using
convolution-based approach
* Evaluate In-Vitro/In-Vivo correlation methods, including
convolution-deconvolution approach using the NONMEM software
* Evaluate the relationship between extended release drug exposure and
clinical response in presence of placebo effect and acute tolerance
* Determine the relationship between drug delivery and clinical
response
* Determine the In-Vitro drug release appropriate for optimizing the
clinical response
* <http://www.pharmacometrica.com/> Determine the optimal study
design methodology for study in a pediatric population for extended =
release
formulations using the PopED software

 

Course objectives

* To develop population PK models for describing multiphase absorption
profiles
* To evaluate alternative placebo response models
* To develop indirect-response model to jointly evaluate the placebo
and drug relate response
* To evaluate the relative impact of the immediate and the delayed
drug release on the therapeutic response
* To use convolution-deconvolution methods for linking in-vitro to
in-vivo outcomes
* To determine the optimal drug formulation profiles for optimizing
the performances of novel drug formulations
* To evaluate optimal study design methodologies
* To present and use in the hands-on session an R based package for
implementing:

a. the convolution/deconvolution analysis,

b. a clinical trial simulator for describing the clinical response in
presence of placebo and active drug response,

c. the estimation of the optimal in-vitro dissolution profiles

 

 

Additional details are available at:
<http://pharmacometricaworkshop.webs.com/>
http://pharmacometricaworkshop.webs.com/

 

 

 

Roberto Gomeni, PhD, HDR, Adjunct Professor at UNC

Pharmacometrica

Longcol, 12270 La Fouillade (France)

E-mail: <mailto:roberto.gomeni_at_pharmacometrica.com>
roberto.gomeni_at_pharmacometrica.com

 <http://www.pharmacometrica.com/> www.pharmacometrica.com

Next workshops on pharmacometrics:
<http://pharmacometricaworkshop.webs.com/>
http://pharmacometricaworkshop.webs.com/

 

 

 





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Received on Wed Sep 02 2015 - 02:03:41 EDT

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