RE: [NMusers] NM-Tran infer data are single subject when perform simulation

From: Lavigne, Jean <jean.lavigne_at_celerion.com>
Date: Thu, 29 Oct 2015 20:05:36 +0000

Dear Tommy,

You may also remove the $COV for the simulations.

Best regards,

Jean

From: owner-nmusers_at_globomaxnm.com [mailto:owner-nmusers_at_globomaxnm.com] On Behalf Of Tommy Li
Sent: Thursday, October 29, 2015 15:04
To: “nmusers_at_globomaxnm.com”
Subject: [NMusers] NM-Tran infer data are single subject when perform simulation

Hello

I have population data set that I fitted to a model. However, when I try to use the exact data set and model to perform simulation, I encounter the situation where NM-Tran infer the data as single subject. Is there a reason why this happens? Also, how do I force NM-Tran to infer data as population for simulation in this case?

To perform simulation I just change from $EST to $SIM. I have done this before with other model and data set before with no problem. I did the same with current model.

Here is the beginning and end of my model code:
$INPUT ID PART TRT PTIM PTM2 TM TSLD AMT D FLAG CMT FBQL EVID MDV AGE SEX WGT HGT BSA DIAB HTN HLIP ETOH SMOK BDAS BSJC BTJC BCRP WBC ALB ALT AST CRCL ACR20 ACR50 ACR70 TIME TIME_ DV DV_ ACR50C ACR50P ACR70C ACR70P KAI CLI VI

$DATA pddataACRTIMECOR.csv IGNORE=_at_

$SUBROUTINES ADVAN6 TOL=10
$SUBROUTINES OTHER=bivariate.f90

$MODEL NCOMP=3 COMP=DEPOT COMP=CENTRAL COMP=EFFECT
$PK
.....
$ERROR
.....
$THETA
.....
$OMEGA
.....
$EST MAX=8000 PRINT=2 METHOD=1 LAPLACE -2LL SIGL=10 NOHABORT
$COV COMPRESS MATRIX=R PRINT=E UNCONDITIONAL

For simulation, I just change the $EST block to $SIM
$SIM (547676) (523842) ONLYSIM SUBPROBLEMS=1

Thank you
Tommy Li


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Received on Thu Oct 29 2015 - 16:05:36 EDT

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