[NMusers] Re: popPDx- error in running the model data set

From: Bharadwaj, Manushree <manushb_at_ostatemail.okstate.edu>
Date: Thu, 22 Oct 2015 09:09:37 -0500

Thank you friends. Your suggestions helped.

Manushree

On Wed, Oct 21, 2015 at 5:14 PM, Bharadwaj, Manushree <
manushb_at_ostatemail.okstate.edu> wrote:

> *Dear friends*,
>
> *I am exploring the popPDx. In the library I found few data sets. I picked
> data1.csv from the library and it looks like below. The ID are from 1 to 6
> and each have 25 observations. Looking at the data I can tell that it is a
> single dose study and 25 samples are collected from each ID. *
> C ID TIME DV AMT RATE 1 0 0 100 0 1 1 11.34 0 0 1 2 3.05 0 0
> *Under the model/run tab, there are many control streams available and the
> one I selected is below (adv10tr1.ctl). The only changes I made in the
> control stream are highlighted green. *
>
> ;Model Desc: One Comp. Michaelis-Menten Model - param: (VM/KM/V)
> ;Project Name: LIBRARY
> ;Project ID: GM00-005
>
> $PROB RUN# adv10tr1 TrialA
> $INPUT C ID TIME DV AMT DROP=RATE EVID ;etc.
> $DATA data1.csv IGNORE=C
> $SUBROUTINE ADVAN10 TRANS1 TOL=5
> $PK
> ;TO NUMBER RECORDS WITHIN AN INDIVIDUAL
> IF(NEWIND.LT.2) INDR=1
> IF(NEWIND.EQ.2) INDR=INDR+1
> IF(TIME.EQ.0) DOSE=AMT ;allows sorting graphs by dose
> TVVM=THETA(1)
> VM=TVVM*EXP(ETA(1))
> TVKM=THETA(2)
> KM=TVKM*EXP(ETA(2))
> TVV=THETA(3)
> V=TVV*EXP(ETA(3))
> S1=V
>
> $ERROR
> IPRE=F
> Y=F + F*ERR(1) +ERR(2)
> CN=F/DOSE
> $THETA
> (0,10) ;[VM]
> (0,10) ;[KM]
> (0,1.0) ;[V]
> $OMEGA
> 0.04 ;[P] INTERINDIVIDUAL VARIABILITY IN VM
> 0.04 ;[P] INTERINDIVIDUAL VARIABILITY IN KM
> 0.04 ;[P] INTERINDIVIDUAL VARIABILITY IN V
> $SIGMA
> 0.1 ;[P] PROPORTIONAL COMPONENT OF RESIDUAL VARIABILITY
> 0.001 ;[A] ADDITIVE COMPONENT OF RESIDUAL VARIABILITY
> ;$MSF
> $ESTIMATION MAXEVAL=9999 PRINT=5 POSTHOC MSF=adv10tr1.MSF
> ;$SIMULATION ONLYSIM (9283745)
> ;$COV
> $TABLE ID TIME DOSE IPRE CN INDR FILE=adv10tr1.tab NOPRINT
> $TABLE ID VM KM V ONEHEADER FILE=patabadv10tr1 NOPRINT
> ;$TABLE ID NOPRINT ONEHEADER FILE=cotab001
> ;$TABLE ID NOPRINT ONEHEADER FILE=catab001
> ;$TABLE ID TIME IPRE NOPRINT ONEHEADER FILE=sdtab001
>
> *On running the model, I got this error message 20 times (I have deleted
> some repetitive text (RECORD 1 to 20) from the error and represented the
> continuation with dotted lines).*
>
> WARNINGS AND ERRORS (IF ANY) FOR PROBLEM 1
>
> (WARNING 2) NM-TRAN INFERS THAT THE DATA ARE POPULATION.
>
> (DATA WARNING 2) RECORD 1, DATA ITEM 6, CONTENTS:
> THE NUMBER OF DATA ITEMS SPECIFIED IN $INPUT EXCEEDS THE NUMBER OF VALUES
> IN A RECORD OF THE NM-TRAN DATA FILE. NULLS WERE SUPPLIED FOR MISSING
> VALUES, STARTING WITH THE ABOVE NUMBERED DATA ITEM.
>
> .....................................................................................................................................................
>
> .....................................................................................................................................................
>
> (DATA WARNING 2) RECORD 20, DATA ITEM 6, CONTENTS:
> THE NUMBER OF DATA ITEMS SPECIFIED IN $INPUT EXCEEDS THE NUMBER OF VALUES
> IN A RECORD OF THE NM-TRAN DATA FILE. NULLS WERE SUPPLIED FOR MISSING
> VALUES, STARTING WITH THE ABOVE NUMBERED DATA ITEM.*
>
> * THE MAXIMUM NUMBER OF WARNINGS OF ONE OR MORE TYPES WAS REACHED.
> IT IS POSSIBLE THAT SOME WARNING MESSAGES WERE SUPPRESSED.
>
> *Could someone please tell me what error is this? As per my knowledge, if
> we ignore C and drop the data item RATE, which has already been specified
> in the $INPUT statement, then there are only 4 data items left (ID TIME DV
> and AMT). So, why did this error occur?*
> *Moreover, what does it mean by "NULLS WERE SUPPLIED FOR MISSING*
> * VALUES, STARTING WITH THE ABOVE NUMBERED DATA ITEM"*
>
> *Thank you,*
> *Manushree*
>
> --
> *With regards-*
> *Manushree Bharadwaj, BVSc, PhD Candidate*
> *Graduate Teaching Associate*
> *Department of Physiological Sciences*
> *Center for Veterinary Health Sciences*
> *Oklahoma State University*
> *Stillwater, OK-74074*
>



--
*With regards-*
*Manushree Bharadwaj, BVSc, PhD Candidate*
*Graduate Teaching Associate*
*Department of Physiological Sciences*
*Center for Veterinary Health Sciences*
*Oklahoma State University*
*Stillwater, OK-74074*

Received on Thu Oct 22 2015 - 10:09:37 EDT

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