[NMusers] popPDx- error in running the model data set

From: Bharadwaj, Manushree <manushb_at_ostatemail.okstate.edu>
Date: Wed, 21 Oct 2015 17:14:48 -0500

*Dear friends*,

*I am exploring the popPDx. In the library I found few data sets. I picked
data1.csv from the library and it looks like below. The ID are from 1 to 6
and each have 25 observations. Looking at the data I can tell that it is a
single dose study and 25 samples are collected from each ID. *
C ID TIME DV AMT RATE 1 0 0 100 0 1 1 11.34 0 0 1 2 3.05 0 0
*Under the model/run tab, there are many control streams available and the
one I selected is below (adv10tr1.ctl). The only changes I made in the
control stream are highlighted green. *

;Model Desc: One Comp. Michaelis-Menten Model - param: (VM/KM/V)
;Project Name: LIBRARY
;Project ID: GM00-005

$PROB RUN# adv10tr1 TrialA
$INPUT C ID TIME DV AMT DROP=RATE EVID ;etc.
$DATA data1.csv IGNORE=C
$SUBROUTINE ADVAN10 TRANS1 TOL=5
$PK
;TO NUMBER RECORDS WITHIN AN INDIVIDUAL
   IF(NEWIND.LT.2) INDR=1
   IF(NEWIND.EQ.2) INDR=INDR+1
  IF(TIME.EQ.0) DOSE=AMT ;allows sorting graphs by dose
  TVVM=THETA(1)
  VM=TVVM*EXP(ETA(1))
  TVKM=THETA(2)
  KM=TVKM*EXP(ETA(2))
  TVV=THETA(3)
  V=TVV*EXP(ETA(3))
  S1=V

$ERROR
  IPRE=F
  Y=F + F*ERR(1) +ERR(2)
  CN=F/DOSE
$THETA
  (0,10) ;[VM]
  (0,10) ;[KM]
  (0,1.0) ;[V]
$OMEGA
  0.04 ;[P] INTERINDIVIDUAL VARIABILITY IN VM
  0.04 ;[P] INTERINDIVIDUAL VARIABILITY IN KM
  0.04 ;[P] INTERINDIVIDUAL VARIABILITY IN V
$SIGMA
  0.1 ;[P] PROPORTIONAL COMPONENT OF RESIDUAL VARIABILITY
  0.001 ;[A] ADDITIVE COMPONENT OF RESIDUAL VARIABILITY
;$MSF
$ESTIMATION MAXEVAL=9999 PRINT=5 POSTHOC MSF=adv10tr1.MSF
;$SIMULATION ONLYSIM (9283745)
;$COV
$TABLE ID TIME DOSE IPRE CN INDR FILE=adv10tr1.tab NOPRINT
$TABLE ID VM KM V ONEHEADER FILE=patabadv10tr1 NOPRINT
;$TABLE ID NOPRINT ONEHEADER FILE=cotab001
;$TABLE ID NOPRINT ONEHEADER FILE=catab001
;$TABLE ID TIME IPRE NOPRINT ONEHEADER FILE=sdtab001

*On running the model, I got this error message 20 times (I have deleted
some repetitive text (RECORD 1 to 20) from the error and represented the
continuation with dotted lines).*

WARNINGS AND ERRORS (IF ANY) FOR PROBLEM 1

 (WARNING 2) NM-TRAN INFERS THAT THE DATA ARE POPULATION.

 (DATA WARNING 2) RECORD 1, DATA ITEM 6, CONTENTS:
 THE NUMBER OF DATA ITEMS SPECIFIED IN $INPUT EXCEEDS THE NUMBER OF VALUES
 IN A RECORD OF THE NM-TRAN DATA FILE. NULLS WERE SUPPLIED FOR MISSING
 VALUES, STARTING WITH THE ABOVE NUMBERED DATA ITEM.
.....................................................................................................................................................
.....................................................................................................................................................

 (DATA WARNING 2) RECORD 20, DATA ITEM 6, CONTENTS:
 THE NUMBER OF DATA ITEMS SPECIFIED IN $INPUT EXCEEDS THE NUMBER OF VALUES
 IN A RECORD OF THE NM-TRAN DATA FILE. NULLS WERE SUPPLIED FOR MISSING
 VALUES, STARTING WITH THE ABOVE NUMBERED DATA ITEM.*

 * THE MAXIMUM NUMBER OF WARNINGS OF ONE OR MORE TYPES WAS REACHED.
 IT IS POSSIBLE THAT SOME WARNING MESSAGES WERE SUPPRESSED.

*Could someone please tell me what error is this? As per my knowledge, if
we ignore C and drop the data item RATE, which has already been specified
in the $INPUT statement, then there are only 4 data items left (ID TIME DV
and AMT). So, why did this error occur?*
*Moreover, what does it mean by "NULLS WERE SUPPLIED FOR MISSING*
* VALUES, STARTING WITH THE ABOVE NUMBERED DATA ITEM"*

*Thank you,*
*Manushree*

--
*With regards-*
*Manushree Bharadwaj, BVSc, PhD Candidate*
*Graduate Teaching Associate*
*Department of Physiological Sciences*
*Center for Veterinary Health Sciences*
*Oklahoma State University*
*Stillwater, OK-74074*

Received on Wed Oct 21 2015 - 18:14:48 EDT

This archive was generated by hypermail 2.3.0 : Fri Sep 27 2019 - 16:46:42 EDT