[NMusers] Phsysiological model

From: Andre Jackson <jacksonan1945_at_gmail.com>
Date: Mon, 5 Oct 2015 13:17:40 -0400

All:

 

I am attempting to take a Physiological model presented in the literature
and place it into Nonmem with the help of the authors. A point was raised
related to centering parameters which I would appreciate some feedback.

 

In the published paper, model parameters such as Cardiac output are
allometrically scaled as power models:

QCO=15.87*(BW)**0.75

and gut metabolism as:

K_Gutmet=THETA(2)*(WT)**0.75)

 

My question is should I use these equations as stated in the publication or
should I center the estimates as e.g.,

 QCO=15.87*(WT/WTstd)**0.75

 

The weights that will be investigated go from 30 kg up to 80 kg.

 

It would also be very helpful if one can give me an explanation as to why or
why not.

 

Thanks

Andre

 



Received on Mon Oct 05 2015 - 13:17:40 EDT

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