Re: [NMusers] BLQ Data

From: Dan Wright <dan.wright_at_otago.ac.nz>
Date: Fri, 2 Oct 2015 16:56:09 +0000



Sent from my iphone

On 3/10/2015, at 5:45 AM, Ahmed Suleiman <a.a.s.a.suleiman_at_gmail.com<mailto=
:a.a.s.a.suleiman_at_gmail.com>> wrote:

Hi Brady,

Have a look at this recently published paper by Ron Keizer and colleagues; =
will answer your question.

"Incorporation of concentration data below the limit of quantification in p=
opulation pharmacokinetic analyses". Keizer et al, Pharmacol Res Perspect, =
2015.

Best Regards,


On Fri, Oct 2, 2015 at 4:22 PM, Moffett, Brady S. <bsmoffet_at_txch.org<mailto=
:bsmoffet_at_txch.org>> wrote:
I am working with TDM data and am wondering when to use the M3 method for d=
ealing with BLQ data, or, when to just exclude data?

For instance: If I have <1% BLQ data in a large dataset (~1000 patients), =
should I just exclude those patients/values? If I just have one patient wi=
th one value BLQ, is it worth using the M3 method for that one patient? Is=
 there a breakpoint for which using these methods does/does not make a diff=
erence?

Thanks in advance...

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--
Ahmed Abbas Suleiman, MSc
PhD Candidate at Bonn University
Institute of Pharmacology - Clinical Pharmacology Unit
Hospital of the University of Cologne
Gleueler Str. 24, 50931 Cologne,
Germany

Received on Fri Oct 02 2015 - 12:56:09 EDT

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