[NMusers] Senior Pharmacometrician position at Sanofi

From: <Christine.Veyrat-Follet_at_sanofi.com>
Date: Fri, 29 May 2015 15:59:26 +0000

Dear all,


Sanofi R&D is seeking a senior pharmacometrician to lead the Modeling & Sim=
ulation Unit of Paris operational centre. The candidate, as a Member of Dru=
g Disposition leadership team, will be responsible for:

Job Responsibilities/Department Description

* Leading a team of pharmacometricians to support projects in oncol=
ogy and other therapeutic areas in the planning, execution interpretation a=
nd prediction of exposure-response analyses for drug development programs a=
cross all Phases.

* Working closely with the global senior scientific advisors on M&S=
 strategies to ensure project team needs are appropriately addressed.

* Accountable for the development and implementation of a clinical =
modeling and simulation plan based on agreed upon best practices (i.e. mode=
l-based drug development).

* Working and communicating effectively with people from diverse sc=
ientific backgrounds in multi-disciplinary development teams providing phar=
macometric/modeling expertise in different therapeutic areas.

* Co-ordinating analyses of pharmacometrics data from preclinical a=
ctivities to support the selection of appropriate candidate compounds for c=
linical development, and characterization of the popPK and PK/PD of project=
s spanning Phase I to Phase IV and life-cycle management.

* Responsible for designing and analyzing the pharmacokinetic and p=
harmacodynamic components of clinical trials in all phases of development.

* Ensuring quality of the study protocols, reports, sections of rep=
orts (e.g., INDs and NDAs) required for regulatory submissions to various h=
ealth authorities (e.g., the FDA and EMA), summaries and publications.

* Implementing innovative quantitative methods to integrate data of=
 pharmacokinetics, biomarkers, and clinical outcome with data of patient ch=
aracteristics and knowledge of disease mechanisms and disease states to fac=
ilitate quantitative decision making.

* Working in compliance with good clinical Practice (GCP) regulatio=
ns and guidance of regulatory authorities.

* Responsible for resource planning, management and administration

* Develops and supports external contacts (investigators, academic =
and regulatory community, partners in collaborations).

Qualifications
Requirements/Skills

* PhD in relevant scientific discipline and demonstrated expertise =
in pharmacometrics and strong quantitative skills (e.g. experience in mecha=
nistic modelling/systems pharmacology, quantitative translational scaling, =
population modelling).

* Understanding of DMPK and pharmacology/ safety aspects of drug di=
scovery and clinical development, and of basic statistics.

* At least 10 years of experience on modelling and simulation in dr=
ug development in the pharmaceutical industry

* Extensive experience leading a team, managing and developing scie=
ntists.

* Excellent written and verbal communication skills, with successfu=
l presentation capabilities.

* Excellent team work and strong communication in a multidisciplina=
ry environment

* Innovative and critical thinking. Customer focus. Process and per=
formance oriented constant drive to improve working practice.

Languages:

Fluent French and English (oral and written)



To apply, please send your CV with references and a letter of motivation t=
o christine.mauriac_at_sanofi.com<mailto:christine.mauriac_at_sanofi.com> or dany=
.renier_at_sanofi.com<mailto:dany.renier_at_sanofi.com> or directly apply on th=
e Sanofi website.



Christine Veyrat-Follet, PhD






Received on Fri May 29 2015 - 11:59:26 EDT

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