[NMusers] Using sparse data to develop Population PK model for pediatrics

From: DAPING ZHANG <daping.debbie.zhang_at_gmail.com>
Date: Tue, 2 Jun 2015 18:29:02 -0700

Dear all,

I would like to develop a population PK model for a drug used in
pediatrics. We got drug concentrations from 15 patients. The drug was given
3 times a day. Only one plasma sample were drawn every week for 4 weeks.
They record the exact sampling time after drug was given. So for each
patient, we had 4 concentrations from 4 weeks.

I assumed all the 4 samples were from one dose and developed a Pop PK
model. This assumption did not consider disease progress and drug
accumulation. The result was still comparable with literature. I will be
very appreciated your comments and suggestions for this model.


Daping Zhang
Ph.D. Candidate
University of Houston

Received on Tue Jun 02 2015 - 21:29:02 EDT

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