[NMusers] Sampling and sample size for pkpd analysis
I would like to apply pkpd-vd analysis to quantify the impact of
HAART(based) prophylaxis to the rate of mother to child transimission
and progression of HIV-1 in mother and child pairs expected to be
followed up for a minimum of 2 years. Can you please assist me on the
1. What are the methods to use for determining the minimum number of
mother and newborn pairs to be included for pkpd-vd analysis?
2. What are the minimum number of blood samples and optimal sampling
times should i collect from both mother and newborn pairs to obtain an
accurate measure of the drug and viral load levels over the 2-year
Primary covariates to be included in the analysis are CYP2B6, CYP3A4 and ABCB1.
Your comments and suggestions are welcome.
PhD Student, University of Zimbabwe
Africa Institute of Biomedical Science and Technology
P. O Box 2294
+263 772 160 896
Received on Tue Feb 17 2015 - 11:38:52 EST
This archive was generated by hypermail 2.3.0
: Fri Sep 27 2019 - 16:43:10 EDT