[NMusers] Sampling and sample size for pkpd analysis

From: Bernard Ngara <bernardngara4_at_gmail.com>
Date: Tue, 17 Feb 2015 18:38:52 +0200

Dear all

I would like to apply pkpd-vd analysis to quantify the impact of
HAART(based) prophylaxis to the rate of mother to child transimission
and progression of HIV-1 in mother and child pairs expected to be
followed up for a minimum of 2 years. Can you please assist me on the
following issues:

1. What are the methods to use for determining the minimum number of
mother and newborn pairs to be included for pkpd-vd analysis?

2. What are the minimum number of blood samples and optimal sampling
times should i collect from both mother and newborn pairs to obtain an
accurate measure of the drug and viral load levels over the 2-year
period?

Primary covariates to be included in the analysis are CYP2B6, CYP3A4 and ABCB1.

Your comments and suggestions are welcome.

Regards

Bernard
PhD Student, University of Zimbabwe

--
Bernard Ngara
Trainee Biostatistician
Africa Institute of Biomedical Science and Technology
P. O Box 2294
Harare
Zimbabwe
+263 772 160 896
Received on Tue Feb 17 2015 - 11:38:52 EST

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