[NMusers] A question about handling large-scale data

From: Liudongyang_hotmail <liudongyang.cp_at_hotmail.com>
Date: Thu, 20 Nov 2014 13:41:47 +0800

Hello All Nonmem Users,


  I am modeling intra-gastric H+ concentrations as PD biomarker, which
varies from 10e-7 to 10e-1. I log-transformed original data and used "Y =
LOG(IPRED)+EPS(1)" as log-linear error model firstly. The profile could be
simulated well, but when I fitted data, error messages as "rounding error ."
or "numerical difficulty ." showed up. Fitting was terminated generally.
Will anybody share their experiences or tips on this kind of data?




Dongyang Liu, Clinical Pharmacologist

Phase I Unit, Clinical Pharmacology Research Center,

Peking Union Medical College Hospital, Beijing, China

M.P.: +86-18610966092

O.P.: +86-10-69158356





Received on Thu Nov 20 2014 - 00:41:47 EST

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