[NMusers] PK/PD jobs for research scientists at Certara

From: Suzanne Minton <Suzanne.Minton_at_certara.com>
Date: Mon, 15 Dec 2014 22:49:16 +0000

At Certara, we're committed to improving human health by offering a broad s=
pectrum of software products and services, with special focus on supporting=
 translational approaches to drug development. Our success depends on peopl=
e who are bright, hard-working, and innovative. Certara operates from its h=
eadquarters in Princeton, New Jersey, USA with additional US offices in Cal=
ifornia, Missouri, and North Carolina, and international offices in France,=
 Germany, the United Kingdom, China, India, and Japan.

Certara offers a full range of competitive benefits. We currently have job =
openings for the following positions:
Sr. Research Scientist
http://www.certara.com/about-us/careers/sr.-research-scientist-product-cham=
pion-pharsight-software

Location: Cary, NC

Reports to: Director, Product Development

The position requires a sound understanding of pharmacometrics with statist=
ical background. Ideally, experience in clinical trial design, adaptive des=
ign, and enrichment design are desirable. Experience in pediatric trial des=
ign will be a plus. This position does not require laboratory or clinical w=
ork. The successful applicant needs to be self-motivated, able to do indepe=
ndent research and development, and excel in a team environment. Clear com=
munication skills are essential. The successful applicant will join an inte=
rnationally recognized, multidisciplinary team and will have the opport=
unity to further develop their knowledge and skills in the area of ph=
armacometrics and systems pharmacology

Key Responsibilities:
* Prototyping new statistical algorithms and new applications of cu=
rrent methods as solutions for pharmaceutical industry problems in the =
PK/PD, bioequivalence assessment and related areas.
* Creating clinical trial simulation examples from both Phoenix NLME and NO=
NMEM with R Script
* Building various PK-PD models and collecting population/disease data/mode=
ls for validation of Pharsight drug clinical development tools
* Testing and prototyping of software products to review existing problems =
and propose solutions.
* Collating and reviewing PK-PD models and data from the scientific literat=
ure
* Recording and mathematically and statistically manipulating information a=
ccurately
* Providing on-going customer support, education and training related to th=
e documentation and use of Phoenix WinNonlin, Phoenix NLME, IVIVC, Trial Si=
mulator, etc.
* Acting as a tutor for workshops
* Participating and representing the company in the pharmacometric communit=
y through meeting attendance (including formal written and oral presentatio=
ns) and contributing to pharmacometric literature
* Staying up-to-date with new technology and developments (e.g., FDA Guidan=
ce) in order to be positioned to recognize emerging opportunities
* Participating in writing scientific reports relevant to projects at work
* Working with projects to review existing problems and propose solutions
* Supporting the implementation of new software development processes and t=
echnologies as well as improvements to current practices
* Helping to shape future product features and functionality

Qualifications:
* Ph.D. degree in a specialty area such as PKPD/Pharmacometrics with a back=
ground in Statistics, Computational/Systems Biology, System Control or Bioe=
ngineering, Mathematics or a related discipline
* 5-10 years of industry/consulting experience (may be combined with academ=
ic research)

Skills & Abilities:
* Well-developed work plan writing skills. Excellent writing, editing, verb=
al communication, and interpersonal skills
* Ability to simultaneously manage multiple projects
* Independent performance of analysis and modeling with little to no superv=
ision and development of reports with minimal modifications required upon r=
eview
* Demonstrable communication skills, as evident by presentation at scientif=
ic meetings, and good interpersonal and organizational skills
* Proficiency in PK/PD software with at least one of the following so=
ftware packages: WinNonlin, Phoenix NLME, Adapt, NONMEM, WinBUGS, MON=
OLIX or any other commonly used PK/PD tool; mathematical analysis/s=
imulation platforms such as Matlab, acslX; statistical software such a=
s S-PLUS/R/SAS
* Proficiency in modeling (e.g., PK and PK/PD analyses, dose-response and e=
xposure-response analyses, disease modeling, trial simulation, optimal stud=
y designs, strategic decision analyses, economic modeling)
* Knowledge of PK/PD properties of small and large molecules, pediatric dru=
g development,
* Knowledge of software development processes and principles of software de=
sign
* Knowledge of parallel programming techniques such as MPI and OpenMP
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Research Scientist
http://www.certara.com/about-us/careers/research-assistant-research-scienti=
st/research-scientist-software-development
Location: Cary, NC
Reports to: Director, Product Management
The position requires a sound understanding of pharmacometrics and systems =
pharmacology. In addition, familiarity with protocols related to the =
 conduct of clinical studies in children and adults are desirable. =
This position does not require laboratory or clinical work. The successful =
applicant needs to be self-motivated, able to do independent research and d=
evelopment, and excel in a team environment. Clear communication skills ar=
e essential. The successful applicant will join an internationally recogniz=
ed, multidisciplinary team and will have the opportunity to further =
develop their knowledge and skills in the area of pharmacometrics and sy=
stems pharmacology.

Responsibilities:

  * Building various PK-PD models and collecting population/disease data/=
models for validation of Pharsight drug clinical development tools.
  * Testing and prototyping of software products to review existing probl=
ems and propose solutions.
  * Collating and reviewing PK-PD models and data from the scientific lit=
erature.
  * Recording and mathematically and statistically manipulating informati=
on accurately.
  * Providing on-going customer support, education and training related t=
o the documentation and use of Phoenix WinNonlin, Phoenix NLME, IVIVC, Tria=
l Simulator, etc.
  * Acting as a tutor for workshops.
  * Participating and representing the company in the pharmacometric comm=
unity through meeting attendance (including formal written and oral present=
ations) and contributing to pharmacometric literature.
  * Staying up-to-date with new technology and developments (e.g., FDA Gu=
idance) in order to be positioned to recognize emerging opportunities.
  * Participating in writing scientific reports relevant to projects at w=
ork.
  * Working with projects to review existing problems and propose solutio=
ns.
  * Supporting the implementation of new software development processes a=
nd technologies as well as improvements to current practices.
  * Helping to shape future product features and functionality.
Qualifications:

  * Bachelor of Science, Master of Science, or Ph.D. degree (or equivalen=
t) in a specialty area such as PKPD/Pharmacometrics; Pharmacology, Toxicolo=
gy, Statistics, Computational/Systems Biology; System Control or Bioenginee=
ring, Mathematics or a related discipline.
  * 3-5 years of industry/consulting experience (may be combined with aca=
demic research).
  * Well-developed work plan writing skills. Excellent writing, editing, =
verbal communication, and interpersonal skills.
  * Ability to simultaneously manage multiple projects.
  * Independent performance of analysis and modeling with little to no su=
pervision and development of reports with minimal modifications required up=
on review.
  * Demonstrable communication skills, as evident by presentation at scie=
ntific meetings, and good interpersonal and organizational skills.
  * Proficiency in PK/PD software with at least one of the following=
  software packages: WinNonlin, Phoenix NLME, Adapt, NONMEM, WinBUGS, =
 MONOLIX or any other commonly used PKPD tool; mathematical analysi=
s/simulation platforms such as Matlab, acslX; statistical software suc=
h as S-PLUS/R/SAS.
  * Good working knowledge of modeling (e.g., PK and PK/PD analyses, dose=
-response and exposure-response analyses, disease modeling, trial simulatio=
n, optimal study designs, strategic decision analyses, economic modeling).
  * Knowledge of PK/PD properties of small and large molecules, pediatric=
 drug development.
  * Knowledge of software development process and principles of software =
design.
  * Knowledge of parallel programming techniques such as MPI and OpenMP.

Applications

Email resume to: hr_at_certara.com

OR Send to:
Attn: Human Resources
Certara
5520 Dillard Dr., Suite 260
Cary, NC 27518 NOTICE: The information contained in this electronic=
 mail message is intended only for the personal and confidential use o=
f the designated recipient(s) named above. This message may be an attorney-=
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nd may be subject to a protective order. As such, this message is privilege=
d and confidential. If the reader of this message is not the intended =
recipient or an agent responsible for delivering it to the intended re=
cipient, you are hereby notified that you have received this message in err=
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ion in error, please notify us immediately by telephone and e-mail and dest=
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d copies or electronically stored copies). Thank you. buSp9xeMeKEbrUze




Received on Mon Dec 15 2014 - 17:49:16 EST

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