RE: [NMusers] NONMEM problem with gcc/gfortran 5.0 under Mac OS 10.10 Yosemite

From: Bauer, Robert <>
Date: Mon, 15 Dec 2014 18:58:23 +0000

The new gfortran compiler appears to report any IEEE signals. Your particular control stream seems to cause a dive-by zero that does not impact your results. Nonetheless, browse through your control stream and very that variables that you divide by are never zero, such as your residual weight value, etc.

Robert J. Bauer, Ph.D.
Vice President, Pharmacometrics, R&D
ICON Development Solutions
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From: [] On Behalf Of Ting-Jie GUO
Sent: Thursday, December 11, 2014 10:33 PM
Subject: [NMusers] NONMEM problem with gcc/gfortran 5.0 under Mac OS 10.10 Yosemite

Dear all,

I encounter a problem after upgrading my mac to Yosemite. I also renew the gcc/gfortran from 4.8 to 5.0 version as Yosemite can't support gcc/gfortran 4.8 well. But there is always a note presented every time when I run NONMEM as follows:

Note: The following floating-point exceptions are signalling: IEEE_INVALID_FLAG IEEE_DIVIDE_BY_ZERO

​which I've never seen before​. I'm sure there's no wrong with control stream. Have anyone ever seen the situation before?


Ting-Jie GUO
Group of Pharmacometrics,
Peking University, China.
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Received on Mon Dec 15 2014 - 13:58:23 EST

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